Shadnoush Mahdi, Momenan Mehrnaz, Seidel Veronique, Tierling Sascha, Fatemi Nayeralsadat, Nazemalhosseini-Mojarad Ehsan, Norooz Mohammad Tayefeh, Cheraghpour Makan
Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, P.O.Box, Tehran, 16635-148, Iran.
Department of Clinical Nutrition & Dietetics, Faculty of Nutrition Science and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Pharmacol Rep. 2025 Feb;77(1):103-123. doi: 10.1007/s43440-024-00652-y. Epub 2024 Sep 20.
Colorectal cancer (CRC) is one of the most common cancers and a major cause of cancer-related mortality worldwide. The efficacy of chemotherapy agents in CRC treatment is often limited due to toxic side effects, heterogeneity of cancer cells, and the possibility of chemoresistance which promotes cancer cell survival through several mechanisms. Combining chemotherapy agents with natural compounds like curcumin, a polyphenol compound from the Curcuma longa plant, has been reported to overcome chemoresistance and increase the sensitivity of cancer cells to chemotherapeutics. Curcumin, alone or in combination with chemotherapy agents, has been demonstrated to prevent chemoresistance by modulating various signaling pathways, reducing the expression of drug resistance-related genes. The purpose of this article is to provide a comprehensive update on studies that have investigated the ability of curcumin to enhance the efficacy of chemotherapy agents used in CRC. It is hoped that it can serve as a template for future research on the efficacy of curcumin, or other natural compounds, combined with chemotherapy agents to maximize the effectiveness of therapy and reduce the side effects that occur in CRC or other cancers.
结直肠癌（CRC）是全球最常见的癌症之一，也是癌症相关死亡的主要原因。由于化疗药物存在毒副作用、癌细胞异质性以及通过多种机制促进癌细胞存活的化疗耐药可能性，其在CRC治疗中的疗效往往受到限制。据报道，将化疗药物与姜黄素等天然化合物联合使用可以克服化疗耐药性，并增加癌细胞对化疗药物的敏感性。姜黄素是一种来自姜黄植物的多酚化合物，单独或与化疗药物联合使用，已被证明可以通过调节各种信号通路、降低耐药相关基因的表达来预防化疗耐药。本文的目的是全面更新关于姜黄素增强CRC化疗药物疗效的研究。希望它能为未来关于姜黄素或其他天然化合物与化疗药物联合使用的疗效研究提供一个模板，以最大限度地提高治疗效果，并减少CRC或其他癌症中出现的副作用。
