Small David M, Beetham Kassia S, Howden Erin J, Briskey David R, Johnson David W, Isbel Nicole M, Gobe Glenda C, Coombes Jeff S
a Centre for Kidney Disease Research, School of Medicine , The University of Queensland, Translational Research Institute , Brisbane , Australia.
b School of Human Movement and Nutrition Sciences , The University of Queensland , Brisbane , Australia.
Redox Rep. 2017 May;22(3):127-136. doi: 10.1080/13510002.2016.1276314. Epub 2017 Jan 11.
Determine the effects of a 12-month exercise and lifestyle intervention program on changes in plasma biomarkers of oxidative stress in pre-dialysis chronic kidney disease (CKD) patients.
A total of 136 stage 3-4 CKD patients were randomized to receive standard nephrological care with (N = 72) or without (N = 64) a lifestyle and exercise intervention for 12 months. Plasma total F-isoprostanes (IsoP), glutathione peroxidase (GPX) activity, total antioxidant capacity (TAC), anthropometric and biochemical data were collected at baseline and at 12 months.
There were no significant differences between groups at baseline. There were no significant differences in changes for standard care and lifestyle intervention, respectively, in IsoP (p = 0.88), GPX (p = 0.87), or TAC (p = 0.56). Patients identified as having high IsoP at baseline (>250 pg/mL) had a greater decrease in IsoP with lifestyle intervention compared to standard care; however, the difference was not statistically significant (p = 0.06). There was no difference in the change in kidney function (eGFR) between standard care and lifestyle intervention (p = 0.33).
Exercise and lifestyle modification in stage 3-4 CKD did not produce changes in systemic biomarkers of oxidative stress over a 12-month period, but patients with high IsoP may benefit most from the addition of intervention to standard care.
确定一项为期12个月的运动和生活方式干预计划对透析前慢性肾脏病（CKD）患者血浆氧化应激生物标志物变化的影响。
总共136例3-4期CKD患者被随机分为两组，一组（N = 72）接受标准肾脏病护理并同时进行生活方式和运动干预，另一组（N = 64）仅接受标准肾脏病护理，为期12个月。在基线和12个月时收集血浆总F-异前列腺素（IsoP）、谷胱甘肽过氧化物酶（GPX）活性、总抗氧化能力（TAC）、人体测量和生化数据。
两组在基线时无显著差异。标准护理组和生活方式干预组在IsoP（p = 0.88）、GPX（p = 0.87）或TAC（p = 0.56）的变化方面均无显著差异。与标准护理相比，基线时IsoP较高（>250 pg/mL）的患者在接受生活方式干预后IsoP下降幅度更大；然而，差异无统计学意义（p = 0.06）。标准护理组和生活方式干预组在肾功能变化（估算肾小球滤过率[eGFR]）方面无差异（p = 0.33）。
3-4期CKD患者进行运动和生活方式改变在12个月期间并未使氧化应激的全身生物标志物发生变化，但IsoP较高的患者可能从在标准护理基础上加用干预措施中获益最多。
