吡唑并氟司他汀 A-C，南海来源玫瑰红红球菌 Micromonospora rosaria SCSIO N160 中吡唑并稠合的苯并[a]荧蒽
Pyrazolofluostatins A-C, Pyrazole-Fused Benzo[a]fluorenes from South China Sea-Derived Micromonospora rosaria SCSIO N160.
机构信息
Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou 510301, China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, P. R. China.
出版信息
Org Lett. 2017 Feb 3;19(3):592-595. doi: 10.1021/acs.orglett.6b03745. Epub 2017 Jan 11.
Pyrazolofluostatins A-C (1-3), three new benzo[a]fluorenes with an unprecedented carbon skeleton, were obtained from the South China Sea-derived Micromonospora rosaria SCSIO N160. Their structures were elucidated by extensive spectroscopic analyses. The structure of pyrazolofluostatin A (1) was confirmed by X-ray crystallographic analysis. Notably, 1-3 possessed a benzo[cd]indeno[2,1-f]indazol skeleton with a pyrazole-fused 6/5/6/6/5 pentacyclic ring system. Pyrazolofluostatin A (1) showed moderate antioxidation activity (EC 48.6 μM).
吡唑并氟他汀 A-C（1-3）是从南海来源的玫瑰红小单孢菌 SCSIO N160 中获得的三种具有前所未有的碳骨架的新型苯并[a]荧蒽。通过广泛的光谱分析阐明了它们的结构。吡唑并氟他汀 A（1）的结构通过 X 射线晶体学分析得到证实。值得注意的是，1-3 具有苯并[cd]茚并[2,1-f]吲哚骨架，带有吡唑稠合的 6/5/6/6/5 五环系统。吡唑并氟他汀 A（1）表现出中等的抗氧化活性（EC 48.6 μM）。
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