Remennick L I
Department of Cancer Epidemiology, All-Union Cancer Research Centre, Moscow, USSR.
Int J Epidemiol. 1989 Sep;18(3):498-510. doi: 10.1093/ije/18.3.498.
Many of the known or suspected risk factors of sex hormone-dependent cancers in women (low parity, delay in childbearing, etc) are typical features of modern reproductive behaviour. Within the USSR regional variations in principal reproductive characteristics and the incidence of breast and cervical cancers have been studied using standard correlation and regression analysis. The associations identified in previous analytical studies are generally present in the overall USSR population. However, the demographic peculiarities of this country (low mean ages at marriage and first birth, high rate of induced abortions, etc) introduce specificity into these relationships. The principal findings are: prevailing influence of parity versus age at first birth on regional variation of breast cancer incidence; consistent association between abortion rates (total, out-of-hospital and in primigravidas) and incidence of both breast and cervical cancers; suggested positive associations of early marriage and first birth with cervical cancer risk. Most of the reproductive variables studied affect the incidence of breast and cervical cancers in opposite ways.
许多已知的或疑似的女性性激素依赖性癌症风险因素（低生育次数、生育延迟等）是现代生殖行为的典型特征。在苏联，运用标准的相关性和回归分析研究了主要生殖特征的地区差异以及乳腺癌和宫颈癌的发病率。先前分析研究中确定的关联在苏联全体人口中普遍存在。然而，该国的人口特征（低结婚年龄和初育年龄、高人工流产率等）使这些关系具有特殊性。主要研究结果如下：生育次数相对于初育年龄对乳腺癌发病率地区差异的主要影响；流产率（总流产率、院外流产率和初产妇流产率）与乳腺癌和宫颈癌发病率之间的一致关联；提示早婚和初育与宫颈癌风险呈正相关。所研究的大多数生殖变量对乳腺癌和宫颈癌发病率的影响方式相反。
