Li Xia, Yu Canqing, Guo Yu, Bian Zheng, Si Jiahui, Yang Ling, Chen Yiping, Ren Xiaolan, Jiang Ge, Chen Junshi, Chen Zhengming, Lv Jun, Li Liming
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.
Chinese Academy of Medical Sciences, Beijing, China.
Heart. 2017 May;103(10):783-789. doi: 10.1136/heartjnl-2016-310462. Epub 2017 Jan 11.
To prospectively examine the association between tea consumption and the risk of ischaemic heart disease (IHD).
Prospective study using the China Kadoorie Biobank; participants from 10 areas across China were enrolled during 2004-2008 and followed up until 31 December 2013. After excluding participants with cancer, heart disease and stroke at baseline, the present study included 199 293 men and 288 082 women aged 30-79 years at baseline. Information on IHD incidence was collected through disease registries and the new national health insurance databases.
During a median follow-up of 7.2 years, we documented 24 665 (7.19 cases/1000 person-years) incident IHD cases and 3959 (1.13 cases/1000 person-years) major coronary events (MCEs). Tea consumption was associated with reduced risk of IHD and MCE. In the whole cohort, compared with participants who never consumed tea during the past 12 months, the multivariable-adjusted HRs and 95% CIs for less than daily and daily tea consumers were 0.97 (0.94 to 1.00) and 0.92 (0.88 to 0.95) for IHD, 0.92 (0.85 to 1.00) and 0.90 (0.82 to 0.99) for MCE. No linear trends in the HRs across the amount of tea were observed in daily consumers for IHD and MCE (P >0.05). The inverse association between tea consumption and IHD was stronger in rural (P 0.006 for IHD, <0.001 for MCE), non-obese (P 0.012 for MCE) and non-diabetes participants (P 0.004 for IHD).
In this large prospective study, daily tea consumption was associated with a reduced risk of IHD.
前瞻性研究饮茶与缺血性心脏病（IHD）风险之间的关联。
使用中国嘉道理生物银行进行前瞻性研究；2004年至2008年期间招募了来自中国10个地区的参与者，并随访至2013年12月31日。在排除基线时患有癌症、心脏病和中风的参与者后，本研究纳入了199293名男性和288082名女性，他们在基线时年龄为30至79岁。通过疾病登记和新的国家医疗保险数据库收集IHD发病率信息。
在中位随访7.2年期间，我们记录了24665例（7.19例/1000人年）IHD发病病例和3959例（1.13例/1000人年）主要冠状动脉事件（MCE）。饮茶与IHD和MCE风险降低相关。在整个队列中，与过去12个月从未饮茶的参与者相比，少于每日饮茶者和每日饮茶者的多变量调整后IHD风险比（HR）及95%置信区间（CI）分别为0.97（0.94至1.00）和0.92（0.88至0.95），MCE的分别为0.92（0.85至1.00）和0.90（0.82至0.99）。对于IHD和MCE，每日饮茶者中未观察到HR随饮茶量的线性趋势（P＞0.05）。饮茶与IHD之间的负相关在农村地区更强（IHD的P=0.006，MCE的P＜0.0
