Kroon Féline P B, Ramiro Sofia, Royston Patrick, Le Cessie Saskia, Rosendaal Frits R, Kloppenburg Margreet
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Department of Statistical Science and MRC Clinical Trials Unit, University College London, London, UK.
Rheumatology (Oxford). 2017 May 1;56(5):745-752. doi: 10.1093/rheumatology/kew483.
The aim was to establish reference curves of the Australian/Canadian Hand Osteoarthritis Index (AUSCAN), a widely used questionnaire assessing hand complaints.
Analyses were performed in a population-based sample, The Netherlands Epidemiology of Obesity study (n = 6671, aged 45-65 years). Factors associated with AUSCAN scores were analysed with ordered logistic regression, because AUSCAN data were zero inflated, dividing AUSCAN into three categories (0 vs 1-5 vs >5). Age- and sex-specific reference curves for the AUSCAN (range 0-60; higher is worse) were developed using quantile regression in conjunction with fractional polynomials. Observed scores in relevant subgroups were compared with the reference curves.
The median age was 56 [interquartile range (IQR): 50-61] years; 56% were women and 12% had hand OA according to ACR criteria. AUSCAN scores were low (median 1; IQR: 0-4). Reference curves where higher for women, and increased moderately with age: 95% percentiles for AUSCAN in men and women were, respectively, 5.0 and 12.3 points for a 45-year-old, and 15.2 and 33.6 points for a 65-year-old individual. Additional associated factors included hand OA, inflammatory rheumatic diseases, FM, socio-economic status and BMI. Median AUSCAN pain subscale scores of women with hand OA lay between the 75th and 90th centiles of the general population.
AUSCAN scores in the middle-aged Dutch population were low overall, and higher in women than in men. AUSCAN reference curves could serve as a benchmark in research and clinical practice settings. However, the AUSCAN does not measure hand complaints specific for hand OA.
旨在建立澳大利亚/加拿大手部骨关节炎指数（AUSCAN）的参考曲线，这是一种广泛用于评估手部不适的问卷。
在基于人群的样本——荷兰肥胖流行病学研究（n = 6671，年龄45 - 65岁）中进行分析。由于AUSCAN数据存在零膨胀现象，将AUSCAN分为三类（0 vs 1 - 5 vs >5），采用有序逻辑回归分析与AUSCAN评分相关的因素。使用分位数回归结合分数多项式生成AUSCAN（范围0 - 60；分数越高情况越差）的年龄和性别特异性参考曲线。将相关亚组中的观察分数与参考曲线进行比较。
中位年龄为56岁[四分位间距（IQR）：50 - 61岁]；56%为女性，根据美国风湿病学会（ACR）标准，12%患有手部骨关节炎。AUSCAN评分较低（中位值为1；IQR：0 - 4）。女性的参考曲线更高，且随年龄适度增加：45岁男性和女性的AUSCAN第95百分位数分别为5.0分和12.3分，65岁个体分别为15.2分和33.6分。其他相关因素包括手部骨关节炎、炎性风湿性疾病、纤维肌痛、社会经济地位和体重指数。患有手部骨关节炎的女性AUSCAN疼痛子量表中位得分处于一般人群的第75至90百分位数之间。
荷兰中年人群的AUSCAN评分总体较低，女性高于男性。AUSCAN参考曲线可作为研究和临床实践中的基准。然而，AUSCAN并未测量手部骨关节炎特有的手部不适。
