Timoney J F, Velineni S, Ulrich B, Blanchard P
Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky 40546, USA.
Department of Microbiology, NYS College of Veterinary Medicine, Cornell University, Ithaca, New York 14850, USA.
Vet Rec. 2017 Apr 8;180(14):358. doi: 10.1136/vr.103868. Epub 2017 Jan 11.
Lancefield group G is a component of the normal urogenital and pharyngeal flora of the cat. It is also frequently implicated in epizootics of severe disease in closed cat colonies and animal shelters. Given the importance of as a feline pathogen and relative lack of published information on characteristics potentially associated with virulence, the authors have compared isolates from healthy and diseased cats in New York and California using fermentation profiles (biotype) and ScM sequences. With few exceptions, isolates associated with disease were biotype 1. Four alleles of were identified of which type 1 dominated in diseased cats. Type 4 allelic variants were found only in healthy cats and all but one were biotype 2. Type 2 and 3 alleles showed extensive N-terminal variation suggesting a plasminogen-binding site as found on the type 1 allele was absent. Cat antisera to ScM were opsonobactericidal, and these potentially protective antibodies increased during convalescence.
兰斯菲尔德G群是猫正常泌尿生殖道和咽部菌群的一个组成部分。它也经常与封闭猫群和动物收容所中的严重疾病流行有关。鉴于其作为猫病原体的重要性以及关于可能与毒力相关特征的已发表信息相对较少，作者使用发酵谱（生物型）和ScM序列比较了纽约和加利福尼亚健康猫和患病猫的分离株。除少数例外，与疾病相关的分离株为生物型1。鉴定出了ScM的四个等位基因，其中1型在患病猫中占主导。4型等位基因变体仅在健康猫中发现，除一个外均为生物型2。2型和3型等位基因显示出广泛的N端变异，表明不存在1型等位基因上发现的纤溶酶原结合位点。针对ScM的猫抗血清具有调理杀菌作用，这些潜在的保护性抗体在恢复期增加。
