Lv Qianying, Zeng Ji, He Long
Department of Nephrology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430016, People's Republic of China.
Department of Clinical Laboratory, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430033, People's Republic of China.
Int J Mol Epidemiol Genet. 2016 Nov 30;7(4):137-140. eCollection 2016.
Fibrosis is the endpoint in many chronic inflammatory diseases and is defined as an abnormal accumulation of extracellular matrix components. Fibrosis can affect almost any tissue, especially heart, lung, liver, and kidney, and numerous studies have been conducted to find satisfactory treatments. Since heparanase is a kind of endo-β-D-glucuronidase that is capable of cleaving heparan sulfate side chains of heparan sulfate proteoglycans on cell surfaces and the extracellular matrix, which further regulate the bioavailability of growth factors (FGF-2, TGF-β). Meanwhile, FGF-2 and TGF-β play a major role in the fibrosis process. Recent studies including ours have consistently demonstrated that heparanase could promote fibrosis process in different organs. Thus in this mini-review, we updated the advancement of heparanase in the regulation of fibrosis generation, and discussed its impact on several critical signaling pathways relevant to fibrosis.
纤维化是许多慢性炎症性疾病的终点，被定义为细胞外基质成分的异常积聚。纤维化几乎可影响任何组织，尤其是心脏、肺、肝脏和肾脏，并且已经开展了大量研究以寻找令人满意的治疗方法。由于乙酰肝素酶是一种内切-β-D-葡萄糖醛酸酶，能够切割细胞表面和细胞外基质上硫酸乙酰肝素蛋白聚糖的硫酸乙酰肝素侧链，进而调节生长因子（FGF-2、TGF-β）的生物利用度。同时，FGF-2和TGF-β在纤维化过程中起主要作用。包括我们的研究在内的近期研究一致表明，乙酰肝素酶可促进不同器官的纤维化进程。因此，在本综述中，我们更新了乙酰肝素酶在调节纤维化发生方面的进展，并讨论了其对与纤维化相关的几个关键信号通路的影响。
