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草莓、韩国覆盆子和桑椹提取物对人卵巢癌A2780细胞的细胞毒性作用

Cytotoxic Effects of Strawberry, Korean Raspberry, and Mulberry Extracts on Human Ovarian Cancer A2780 Cells.

作者信息

Lee Dahae, Kang Ki Sung, Lee Sanghyun, Cho Eun Ju, Kim Hyun Young

机构信息

Department of Food Science, Gyeongnam National University of Science and Technology, Gyeongnam 52725, Korea.

College of Korean Medicine, Gachon University, Gyeonggi 13120, Korea.

出版信息

Prev Nutr Food Sci. 2016 Dec;21(4):384-388. doi: 10.3746/pnf.2016.21.4.384. Epub 2016 Dec 31.

DOI:10.3746/pnf.2016.21.4.384
PMID:28078263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5216892/
Abstract

Reactive oxygen species are tumorigenic by their ability to increase cell proliferation, survival, and cellular migration. The purpose of the present study was to compare the antioxidant activity and cytotoxic effects of 3 berry extracts (strawberry, Korean raspberry, and mulberry) in A2780 human ovarian carcinoma cells. Except for raspberry, the ethyl acetate or methylene chloride fractions of berries containing phenolic compounds exerted dose dependent free radical scavenging activities. In the raspberry fractions, the hexane fraction also exhibited potent antioxidant activity. The cytotoxic effects of berries extracts in A2780 human ovarian carcinoma cells were measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Surprisingly, co-treatment with -butanol (BuOH) fractions of berries showed stronger cytotoxic effects compared to the other fractions. These findings suggest that potent anticancer molecules are found in the BuOH fractions of berries that have stronger cytotoxic activity than antioxidants.

摘要

活性氧因其具有促进细胞增殖、存活及细胞迁移的能力而具有致瘤性。本研究旨在比较3种浆果提取物（草莓、山莓和桑椹）对A2780人卵巢癌细胞的抗氧化活性和细胞毒性作用。除山莓外，含有酚类化合物的浆果的乙酸乙酯或二氯甲烷馏分具有剂量依赖性的自由基清除活性。在山莓馏分中，己烷馏分也表现出较强的抗氧化活性。采用3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐法测定浆果提取物对A2780人卵巢癌细胞的细胞毒性作用。令人惊讶的是，与其他馏分相比，浆果的正丁醇（BuOH）馏分联合处理显示出更强的细胞毒性作用。这些发现表明，在浆果的BuOH馏分中发现了具有强细胞毒性活性的强效抗癌分子，其细胞毒性活性强于抗氧化剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed76/5216892/e5f9286171eb/pnfs-21-384f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed76/5216892/ed28b2ff2ee0/pnfs-21-384f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed76/5216892/171b389d57cb/pnfs-21-384f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed76/5216892/e80815960c2e/pnfs-21-384f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed76/5216892/e5f9286171eb/pnfs-21-384f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed76/5216892/ed28b2ff2ee0/pnfs-21-384f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed76/5216892/171b389d57cb/pnfs-21-384f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed76/5216892/e80815960c2e/pnfs-21-384f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed76/5216892/e5f9286171eb/pnfs-21-384f4.jpg

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本文引用的文献

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