Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung 40242, Taiwan. ; Institute of Biochemistry and Biotechnology, Medical College, Chung Shan Medical University, Taichung 40242, Taiwan. ; Clinical laboratory, Chung Shan Medical University Hospital, Taichung 40242, Taiwan.
Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung 40242, Taiwan.
J Tradit Complement Med. 2013 Jan;3(1):7-15. doi: 10.4103/2225-4110.106535.
Mulberry ( sāng shèn zǐ), a traditional Chinese medicine (TCM) in Taiwan, has many bioactive substances, including polyphenol and anthocyanins compounds. Over the past decade, many scientific and medical studies have examined mulberry fruit for its antioxidation and antiinflammation effects both in vitro and in vivo. This review thus focuses on the recent advances of mulberry extracts (MEs) and their applications in the prevention and treatment of human cancer, liver disease, obesity, diabetes, and cardiovascular disease. The ME modulates several apoptotic pathways and matrix metalloproteinases (MMPs) to block cancer progression. Mulberry can increase detoxicated and antioxidant enzyme activities and regulate the lipid metabolism to treat hepatic disease resulting from alcohol consumption, high fat diet, lipopolysaccharides (LPS) and CCl4 exposure. Of the various compounds in ME, cyanidin 3-glucoside (C3G) is the most abundant, and the active compound studied in mulberry research. Herein, the antioxidant and antiinflammatory actions of C3G to improve diabetes and cardiovascular disease are also discussed. These studies provide strong evidence ME may possess the bioactivity to affect the pathogenesis of several chronic diseases.
桑树（桑甚子）是台湾的一种传统中药，含有许多生物活性物质，包括多酚和花青素化合物。在过去的十年中，许多科学和医学研究已经在体外和体内研究了桑椹果实的抗氧化和抗炎作用。因此，本综述重点介绍了桑椹提取物（MEs）的最新进展及其在预防和治疗人类癌症、肝病、肥胖症、糖尿病和心血管疾病方面的应用。ME 可调节几种凋亡途径和基质金属蛋白酶（MMPs），从而阻止癌症的进展。桑椹可以增加解毒和抗氧化酶的活性，调节脂质代谢，治疗由饮酒、高脂肪饮食、脂多糖（LPS）和 CCl4 暴露引起的肝病。在 ME 中的各种化合物中，矢车菊素 3-葡萄糖苷（C3G）含量最丰富，也是桑椹研究中研究最活跃的化合物。本文还讨论了 C3G 的抗氧化和抗炎作用，以改善糖尿病和心血管疾病。这些研究为 ME 可能具有影响几种慢性疾病发病机制的生物活性提供了有力证据。
