Division of Gastroenterology & Hepatology, Mayo Clinic, 200 First Street, S.W., Rochester, MN, 55905, USA.
Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Abdom Radiol (NY). 2017 Feb;42(2):351-360. doi: 10.1007/s00261-016-1034-y.
Celiac disease (CD) is an immune-mediated inflammatory enteropathy triggered by gluten exposure in genetically susceptible individuals. It has a high prevalence approaching 1% of the US population. A high index of suspicion is warranted to diagnose CD as frequently patients present with extraintestinal or atypical manifestations. CD is diagnosed by a combination of serum serologies and duodenal biopsies. The majority of patients will respond to a lifelong gluten-free diet which is the cornerstone of therapy. Complications such as refractory CD, ulcerative jejunoileitis, enteropathy associated T-cell lymphoma and small bowel adenocarcinoma occur in a minority of patients.
乳糜泻（CD）是一种由遗传易感个体暴露于麸质引起的免疫介导的炎症性肠病。它的患病率很高，接近美国人口的 1%。由于患者常表现出肠外或非典型表现，因此需要高度怀疑以诊断 CD。CD 通过血清学检查和十二指肠活检相结合来诊断。大多数患者将对终生无麸质饮食有反应，这是治疗的基石。少数患者会出现难治性 CD、溃疡性空肠回肠炎、肠病相关 T 细胞淋巴瘤和小肠腺癌等并发症。
