Niknam Ramin, Jafari Peyman, Safarpour Ali Reza, Shojaei-Zarghani Sara, Fattahi Mohammad Reza
Professor, Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Professor, Department of Biostatistics, Shiraz University of Medical Sciences, Shiraz, Iran.
Middle East J Dig Dis. 2023 Apr;15(2):126-132. doi: 10.34172/mejdd.2023.331. Epub 2023 Apr 30.
Health-related quality of life (HRQOL) assessment in patients with celiac disease (CD) leads to understanding the impact of the CD and interventions on the individual and society. The aim of this study was transcultural adaptation and evaluation of the reliability and validity of the standardized questionnaire of celiac disease quality of life (CD-QOL) in the Persian language in southwest Iran. 150 adults with CD were randomly selected from the celiac clinic and Fars Celiac Registry to complete the New Persian version of the CD-QOL questionnaire. Transcultural adaptation of the questionnaire was conducted by a four-step procedure. The internal consistency of the CD-QOL subscales and convergent and discriminant validity were assessed using Cronbach's alpha coefficient and Spearman's correlation, respectively. Construct validity was evaluated by exploratory and confirmatory factor analysis. All domains of the CD-QOL questionnaire had acceptable internal consistency, showing excellent reliability. The scaling success rates for convergent and discriminant validity were also within an acceptable range (87-100%). In the factor analysis model, similar to the original English version, four factors were extracted characterizing the patients' answers (limitations, dysphoria, health concerns, and inadequate treatment). Our Persian version of the CD-QOL questionnaire had high reliability and validity and could be used in clinical practice assessing the CD-specific HRQOL in the Iranian population.
乳糜泻（CD）患者的健康相关生活质量（HRQOL）评估有助于了解CD及其干预措施对个人和社会的影响。本研究的目的是对伊朗西南部波斯语版的乳糜泻生活质量标准化问卷（CD-QOL）进行跨文化调适，并评估其信度和效度。从乳糜泻诊所和法尔斯乳糜泻登记处随机选取150名成年CD患者，以完成波斯语新版的CD-QOL问卷。问卷的跨文化调适通过四个步骤进行。分别使用克朗巴哈α系数和斯皮尔曼相关性评估CD-QOL分量表的内部一致性以及收敛效度和区分效度。通过探索性和验证性因素分析评估结构效度。CD-QOL问卷的所有领域都具有可接受的内部一致性，显示出出色的信度。收敛效度和区分效度的标度成功率也在可接受范围内（87%-100%）。在因素分析模型中，与原始英文版类似，提取了四个表征患者答案的因素（限制、烦躁不安、健康问题和治疗不足）。我们的波斯语版CD-QOL问卷具有较高的信度和效度，可用于临床实践中评估伊朗人群中特定于CD的HRQOL。
