Nedyalkova Miroslava A, Donkova Borjana V, Simeonov Vasil D
University of Sofia, Faculty of Chemistry and Pharmacy, 1 J. Bourchier Ave, 1164 Sofia, Bulgaria.
J AOAC Int. 2017 Mar 1;100(2):359-364. doi: 10.5740/jaoacint.16-0413. Epub 2017 Jan 12.
Studies of the ecotoxicological aspects of nanomaterials in aquatic environments are scarce. Given the growing variety of nanoparticles (NPs), along with the diversity of aquatic species and environments, the key to promoting sound risk assessment in nanoecotoxicology is understanding the mechanisms that govern the fate of NPs in aquatic environments and their behavior at the NP-biota interface. In this paper, data collected from the literature on ecotoxicological effects observed in aquatic species is discussed and analyzed using multivariate statistics techniques. We expand the knowledge of the environmental impact of silver NPs (AgNPs) by testing the acute toxicity of 47 AgNPs on crustacean eukaryotic organisms (Daphnia magna, Thamnocephalus platyurus, and D. galeata). Physicochemical properties, stabilization agents, toxicological end points, and test media were monitored as adding-outcome factors for the evaluation of environmental effects due to exposure to NPs. The chemometrics expertise performed by the use of hierarchical and nonhierarchical cluster analysis and principal component analysis revealed specific links between the ecotoxicology and the physicochemical features of NPs and helped in creating specific patterns of NPs discriminated by ecotoxicity levels and physicochemical parameters.
关于纳米材料在水生环境中的生态毒理学方面的研究稀缺。鉴于纳米颗粒（NP）种类不断增加，以及水生物种和环境的多样性，促进纳米生态毒理学中合理风险评估的关键在于了解控制NP在水生环境中归宿的机制及其在NP-生物群界面的行为。本文讨论并分析了从文献中收集的关于在水生物种中观察到的生态毒理学效应的数据，采用多元统计技术。我们通过测试47种银纳米颗粒（AgNP）对甲壳类真核生物（大型溞、扁头褶胸鱼蚤和盔形溞）的急性毒性，扩展了对AgNP环境影响的认识。物理化学性质、稳定剂、毒理学终点和测试介质作为附加结果因素进行监测，以评估由于接触NP而产生的环境影响。通过使用层次聚类分析和非层次聚类分析以及主成分分析进行的化学计量学专业分析揭示了生态毒理学与NP物理化学特征之间的特定联系，并有助于创建按生态毒性水平和物理化学参数区分的NP特定模式。
