嵌入纳米凝胶的温度响应性脂质液晶层

Temperature responsive lipid liquid crystal layers with embedded nanogels.

作者信息

Dabkowska A P, Hirst C, Valldeperas M, Clifton L A, Montis C, Nöjd S, Gentile L, Wang M, Pálsson G K, Lages S, Berti D, Barauskas J, Nylander T

机构信息

Division of Physical Chemistry, Lund University, P.O. Box 124, SE-22100 Lund, Sweden.

ISIS Pulsed Neutron and Muon Source, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Oxford Campus, Didcot, Oxfordshire OX11 OQX, UK.

出版信息

Chem Commun (Camb). 2017 Jan 24;53(8):1417-1420. doi: 10.1039/c6cc09426k.

DOI:10.1039/c6cc09426k

PMID:28079197

Abstract

Polymer nanogels are embedded within layers consisting of a nonlamellar liquid crystalline lipid phase to act as thermoresponsive controllers of layer compactness and hydration. As the nanogels change from the swollen to the collapsed state via a temperature trigger, they enable on-demand release of water from the mixed polymer-lipid layer while the lipid matrix remains intact. Combining stimuli-responsive polymers with responsive lipid-based mesophase systems opens up new routes in biomedical applications such as functional biomaterials, bioanalysis and drug delivery.

摘要

聚合物纳米凝胶嵌入由非层状液晶脂质相组成的层中，作为层致密性和水合作用的热响应控制器。随着纳米凝胶通过温度触发从溶胀状态转变为塌陷状态，它们能够在脂质基质保持完整的情况下，按需从聚合物 - 脂质混合层中释放水。将刺激响应性聚合物与基于脂质的响应性中间相系统相结合，为生物医学应用开辟了新途径，如功能生物材料、生物分析和药物递送。