Department of Rheumatology, Rehabilitation and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland.
Oxid Med Cell Longev. 2022 Oct 5;2022:1582432. doi: 10.1155/2022/1582432. eCollection 2022.
Fibromyalgia (FM) is characterized by chronic widespread musculoskeletal pain associated with sleep problems, fatigue, depression, and anxiety. The persistence of pain, impairment of cognitive function, and negative impact on the psychological state have caused a detrimental effect on the patients' quality of life. However, to date, the treatment and mechanisms of this disease are yet to be established. Oxidative stress might play a critical role in FM pathophysiology. Increased levels of prooxidative factors such as nitric oxide, lipid peroxidation, and mitophagy can cause pain sensitization in fibromyalgia. Numerous studies have supported the hypothesis of beneficial antioxidative effects in FM. Due to the lack of effective therapy for fibromyalgia, many treatments are sought to reduce pain and fatigue and improve patients' quality of life. This manuscript discusses the impact of various antioxidative procedures that can diminish fibromyalgia symptoms, such as hyperbaric oxygen therapy, modification of dietary habits, and physical activity.
纤维肌痛（FM）的特征是慢性广泛的肌肉骨骼疼痛，伴有睡眠问题、疲劳、抑郁和焦虑。疼痛的持续存在、认知功能的损害以及对心理状态的负面影响，对患者的生活质量造成了不利影响。然而，迄今为止，这种疾病的治疗和机制尚未建立。氧化应激可能在 FM 的病理生理学中发挥关键作用。一氧化氮、脂质过氧化和线粒体自噬等促氧化因子水平的增加会导致纤维肌痛中的疼痛敏化。许多研究支持 FM 中具有抗氧化作用的假说。由于缺乏有效的纤维肌痛治疗方法，因此寻求了许多治疗方法来减轻疼痛和疲劳，改善患者的生活质量。本文讨论了各种抗氧化程序对减轻纤维肌痛症状的影响，如高压氧治疗、饮食习惯的改变和体育活动。
