Casas-Barragán Antonio, Molina Francisco, Tapia-Haro Rosa María, Martínez-Martos José Manuel, Ramírez-Expósito María Jesús, Rus Alma, Correa-Rodríguez María, Aguilar-Ferrándiz María Encarnación
Department of Physical Therapy, Faculty of Health Sciences, University of Granada (UGR), 18071 Granada, Spain.
Instituto de Investigación Biosanitaria ibs.GRANADA, 18012 Granada, Spain.
Int J Mol Sci. 2024 Dec 17;25(24):13517. doi: 10.3390/ijms252413517.
The aim of this study was to analyze the association between circulating amino acids and central and peripheral body temperature in subjects with and without fibromyalgia syndrome (FMS). A total of 47 patients with FMS and 59 healthy subjects were included in the study. The concentration of amino acids was determined in serum samples using a fluorimeter coupled with a high-performance liquid chromatography system. An infrared thermography camera was used to estimate peripheral hand temperatures. The core temperature of the body was estimated using an infrared thermometer, which was applied to the axillary and tympanic areas. Correlations between several thermographic variables of the hands and tryptophan, methionine, 3-methylhistidine, histidine, glutamic acid, and tyrosine were identified exclusively within the FMS group. In contrast, correlations between aminoadipic acid and serine and thermographic variables were observed only in the healthy control group. The concentrations of asparagine and lysine correlated with thermographic variables in both groups. The essential amino acid leucine was found to correlate with axillary temperature in FMS patients. However, it should be noted that the observed associations between aminoadipic acid and tryptophan blood concentrations and axillary temperature were limited to the control group. Several correlations were identified between circulating amino acids and different body temperatures in both healthy controls and patients with FMS. However, the correlation pattern differs significantly between FMS patients and healthy controls. These findings suggest the possibility of a change in the function of several amino acids in the thermoregulatory process in patients with FMS.
本研究的目的是分析患有和未患有纤维肌痛综合征（FMS）的受试者体内循环氨基酸与中枢和外周体温之间的关联。共有47名FMS患者和59名健康受试者纳入本研究。使用与高效液相色谱系统联用的荧光计测定血清样本中氨基酸的浓度。使用红外热成像相机估计手部外周温度。使用红外温度计估计身体的核心温度，该温度计应用于腋窝和鼓膜区域。仅在FMS组中发现手部的几个热成像变量与色氨酸、蛋氨酸、3-甲基组氨酸、组氨酸、谷氨酸和酪氨酸之间存在相关性。相比之下，仅在健康对照组中观察到氨基己二酸和丝氨酸与热成像变量之间的相关性。两组中天冬酰胺和赖氨酸的浓度均与热成像变量相关。发现必需氨基酸亮氨酸与FMS患者的腋窝温度相关。然而，应注意的是，观察到的氨基己二酸和色氨酸血浓度与腋窝温度之间的关联仅限于对照组。在健康对照组和FMS患者中均发现循环氨基酸与不同体温之间存在几种相关性。然而，FMS患者和健康对照组之间的相关模式存在显著差异。这些发现表明FMS患者在体温调节过程中几种氨基酸的功能可能发生变化。
