Long Ying, Tan Jiewen, Nie Yulin, Lu Yu, Mei Xiufang, Tu Chaoqun
a Department of Hyperbaric Oxygen Treatment , Shenzhen People's Hospital , Shenzhen , P. R. China.
b Department of Hyperbaric Oxygen Treatment , Sun Yat-Sen, Memorial Hospital, Sun Yat-Sen University , Guangzhou , P. R. China.
Neurol Res. 2017 Mar;39(3):239-247. doi: 10.1080/01616412.2016.1275454. Epub 2017 Jan 12.
To observe the effects of hyperbaric oxygen (HBO) therapy on the treatment of sleep disorders and its safety in children with cerebral palsy (CP).
A total of 71 recruited children were divided into two groups based on age: group 1, aged between 2 and 4 years; and group 2, aged between 4 and 6 years. The effects of HBO therapy on sleep quality were observed.
The total sleep items (TSIs) were significantly different in the two groups between pre-HBO, post 10 HBO sessions, and post 20 HBO sessions (p < 0.01). A total of 15/38 (39.5%) participants in group 1 and 8/21 (38.0%) in group 2 presented difficulty in falling asleep; 17/38 (44.7%) in group 1 and 4/21 (19.0%) in group 2 had a short duration of sleep during the night; and 20/38 (52.6%) in group 1 and 11/21 (52.4%) in group 2 woke up easily in the night. No significant difference in the average TSIs in 59 participants was found after 10 HBO sessions. Eight participants had insomnia after the first 5 sessions, and three in group 2 had nocturnal hyperkinesia after 15 sessions. A seizure during decompression was observed in 2/59 participants (2/419 sessions).
These results indicate that HBO therapy is beneficial to improve sleep and is safe for children with CP; however, further studies are necessary to explore the mechanisms of HBO on sleep.
观察高压氧（HBO）治疗对脑瘫（CP）患儿睡眠障碍的治疗效果及其安全性。
将招募的71名儿童按年龄分为两组：第1组，年龄在2至4岁之间；第2组，年龄在4至6岁之间。观察HBO治疗对睡眠质量的影响。
两组在HBO治疗前、10次HBO治疗后和20次HBO治疗后的总睡眠项目（TSIs）有显著差异（p<0.01）。第1组38名参与者中有15名（39.5%）、第2组21名参与者中有8名（38.0%）存在入睡困难；第1组38名中有17名（44.7%）、第2组21名中有4名（19.0%）夜间睡眠时间短；第1组38名中有20名（52.6%）、第2组21名中有11名（52.4%）夜间易醒。10次HBO治疗后，59名参与者的平均TSIs无显著差异。8名参与者在前5次治疗后出现失眠，第2组有3名在15次治疗后出现夜间多动。在59名参与者中观察到2例（共419次治疗中的2例）减压期间癫痫发作。
这些结果表明，HBO治疗有利于改善CP患儿的睡眠且安全；然而，有必要进一步研究HBO改善睡眠的机制。
