Howell Elizabeth A, Egorova Natalia N, Janevic Teresa, Balbierz Amy, Zeitlin Jennifer, Hebert Paul L
Departments of Population Health Science & Policy and Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York; Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Center for Epidemiology and Biostatistics Sorbonne Paris Cité, DHU Risks in pregnancy, Paris Descartes University, Paris, France; and the University of Washington School of Public Health, Seattle, Washington.
Obstet Gynecol. 2017 Feb;129(2):285-294. doi: 10.1097/AOG.0000000000001864.
To investigate differences in severe maternal morbidity between Hispanic mothers and three major Hispanic subgroups compared with non-Hispanic white mothers and the extent to which differences in delivery hospitals may contribute to excess morbidity among Hispanic mothers.
We conducted a population-based cross-sectional study using linked 2011-2013 New York City discharge and birth certificate data sets (n=353,773). Rates of severe maternal morbidity were calculated using a published algorithm based on diagnosis and procedure codes. Mixed-effects logistic regression with a random hospital-specific intercept was used to generate risk-standardized severe maternal morbidity rates for each hospital taking into consideration patient sociodemographic characteristics and comorbidities. Differences in the distribution of Hispanic and non-Hispanic white deliveries were assessed among these hospitals in relation to their risk-adjusted morbidity. Sensitivity analyses were conducted after excluding isolated blood transfusion from the morbidity composite.
Severe maternal morbidity occurred in 4,541 deliveries and was higher among Hispanic than non-Hispanic white women (2.7% compared with 1.5%, P<.001); this rate was 2.9% among those who were Puerto Rican, 2.7% among those who were foreign-born Dominican, and 3.3% among those who were foreign-born Mexican. After adjustment for patient characteristics, the risk remained elevated for Hispanic women (odds ratio [OR] 1.42, 95% confidence interval [CI] 1.22-1.66) and for all three subgroups compared with non-Hispanic white women (P<.001). Risk for Hispanic women was attenuated in sensitivity analyses (OR 1.17, 95% CI 1.02-1.33). Risk-standardized morbidity across hospitals varied sixfold. We estimate that Hispanic-non-Hispanic white differences in delivery location may contribute up to 37% of the ethnic disparity in severe maternal morbidity rates in New York City hospitals.
Hispanic compared with non-Hispanic white mothers are more likely to deliver at hospitals with higher risk-adjusted severe maternal morbidity rates and these differences in site of delivery may contribute to excess morbidity among Hispanic mothers. Our results suggest improving quality at the lowest performing hospitals could benefit both non-Hispanic white and Hispanic women and reduce ethnic disparities in severe maternal morbidity rates.
调查西班牙裔母亲与三个主要西班牙裔亚组相比,与非西班牙裔白人母亲相比,严重孕产妇发病率的差异,以及分娩医院的差异在多大程度上可能导致西班牙裔母亲发病率过高。
我们使用2011 - 2013年纽约市出院和出生证明数据集(n = 353,773)进行了一项基于人群的横断面研究。使用基于诊断和程序代码的已发表算法计算严重孕产妇发病率。使用具有随机医院特定截距的混合效应逻辑回归,考虑患者的社会人口统计学特征和合并症,为每家医院生成风险标准化的严重孕产妇发病率。在这些医院中,评估西班牙裔和非西班牙裔白人分娩分布的差异与其风险调整后的发病率之间的关系。在从发病率综合指标中排除单纯输血后进行敏感性分析。
4541例分娩中发生了严重孕产妇发病,西班牙裔女性的发病率高于非西班牙裔白人女性(2.7% 对1.5%,P <.001);波多黎各裔的发病率为2.9%,外国出生的多米尼加裔为2.7%,外国出生的墨西哥裔为3.3%。在调整患者特征后,西班牙裔女性的风险仍然升高(优势比[OR] 1.42,95%置信区间[CI] 1.22 - 1.66),与非西班牙裔白人女性相比,所有三个亚组的风险也升高(P <.001)。在敏感性分析中,西班牙裔女性的风险有所降低(OR 1.17,95% CI 1.02 - 1.33)。各医院的风险标准化发病率相差六倍。我们估计,纽约市医院中西班牙裔与非西班牙裔白人在分娩地点上的差异可能导致严重孕产妇发病率种族差异的37%。
与非西班牙裔白人母亲相比,西班牙裔母亲更有可能在风险调整后的严重孕产妇发病率较高的医院分娩,而分娩地点的这些差异可能导致西班牙裔母亲发病率过高。我们的结果表明,改善表现最差医院的质量可能使非西班牙裔白人和西班牙裔女性都受益,并减少严重孕产妇发病率的种族差异。