Cannizzo Sarah A, Langan Jennifer N, Warneke Mark, Allender Matthew
J Zoo Wildl Med. 2016 Dec;47(4):977-983. doi: 10.1638/2016-0009.1.
This study evaluated results from an in-house (IH) laboratory dipstick, a reference laboratory (RL) urinalysis, and urine protein : creatinine (UPC) ratios from callimicos ( Callimico goeldii ). Urine was collected from 25 individuals comprising a single colony under professional care in North America and compared based on laboratory, sex, age class, and presence or absence of a normal urinalysis. Urine specific gravity and pH between laboratories were statistically different. Overall, 56% to 100% of animals had at least a trace amount of protein in their urine. In comparing normal and abnormal urinalyses, IH dipstick protein, RL dipstick protein, RL pH, quantitative protein measurement, and UPC ratios were all statistically different. Eleven animals (44%) had UPC ratios that were ≥0.5. Based on results of this study, UPC > 0.3 was found to be abnormal and supportive of renal compromise in callimicos. Higher protein concentrations on the IH dipstick, the quantitative protein concentration, and UPC ratio in the 1- to 4-yr-old age class were the only significant age-related differences. There was no association between any categorical variable (glucose, blood, bilirubin, ketones, urobilinogen) and abnormal urinalysis. There were no differences between sexes. Since renal disease is a major cause of morbidity and mortality in this species, the authors recommend including routine urinalyses and UPC ratios as part of preventive care programs for callimicos. These data provide the first published information on urinalysis and UPC ratios in callimicos and will serve as a helpful reference for interpreting results and evaluating patients with renal disease.
本研究评估了一种内部（IH）实验室试纸条检测结果、参考实验室（RL）的尿液分析结果以及来自狨（Callimico goeldii）的尿蛋白：肌酐（UPC）比值。从北美专业照料下的一个单一种群的25只个体中收集尿液，并根据实验室检测、性别、年龄组以及尿液分析是否正常进行比较。各实验室之间的尿比重和pH存在统计学差异。总体而言，56%至100%的动物尿液中至少含有微量蛋白质。在比较正常和异常尿液分析时，IH试纸条蛋白、RL试纸条蛋白、RL pH、定量蛋白测量以及UPC比值均存在统计学差异。11只动物（44%）的UPC比值≥0.5。基于本研究结果，发现UPC>0.3为异常，提示狨存在肾脏损害。1至4岁年龄组的IH试纸条上较高的蛋白浓度、定量蛋白浓度以及UPC比值是仅有的与年龄相关的显著差异。任何分类变量（葡萄糖、血液、胆红素、酮体、尿胆原）与异常尿液分析之间均无关联。两性之间无差异。由于肾脏疾病是该物种发病和死亡的主要原因，作者建议将常规尿液分析和UPC比值纳入狨的预防保健计划。这些数据提供了关于狨尿液分析和UPC比值的首个公开信息，将有助于解释检测结果并评估肾病患者。
