Friendship Hospital for Animals, Washington, District of Columbia.
University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania.
J Vet Intern Med. 2020 Mar;34(2):777-782. doi: 10.1111/jvim.15735. Epub 2020 Feb 13.
Recently, urine protein:creatinine ratios (UPC) were shown to be lower in urine samples from dogs collected at home (AH) as compared to those collected in hospital (IH). Stress-inducing procedures and travel to the hospital have been hypothesized to cause prerenal proteinuria.
Evaluate patient stress using urine cortisol:creatinine ratios (UCCr) and correlate UCCr to UPC in urine samples obtained AH and IH.
Thirty-six healthy, client-owned dogs.
Prospective, non-masked study. Two voided urine samples were obtained (AH and IH). Complete urinalysis as well as UPC and UCCr were performed. Clients graded their dogs' stress level AH, in transport, and IH.
The UCCr was significantly higher in IH samples than in AH samples (P < .0001), but UPC was not significantly different between AH and IH urine samples (P = .14). In all samples and in both collection settings, UCCr was not significantly correlated with UPC. Travel time and time IH were not correlated with change in UCCr or UPC. In 8 dogs with borderline or overt proteinuria, no significant difference was found in UPC between settings, but UCCr was significantly higher in IH samples.
The UPC was not higher when measured in urine samples collected IH compared to AH. Dogs had higher UCCr IH, but UCCr was not associated with UPC. Stress, as estimated by UCCr, did not affect proteinuria. Further evidence is needed to support the claim that stress may result in proteinuria in healthy dogs.
最近，与在医院（IH）采集的尿液样本相比，在家（AH）采集的犬尿液样本中的尿蛋白与肌酐比值（UPC）较低。应激诱导的程序和前往医院的旅行被认为会导致肾前性蛋白尿。
使用尿皮质醇与肌酐比值（UCCr）评估患者的应激程度，并将 AH 和 IH 采集的尿液样本中的 UCCr 与 UPC 进行相关性分析。
36 只健康的、有主人的犬。
前瞻性、非盲法研究。采集 2 份犬的尿液样本（AH 和 IH）。进行完整的尿液分析以及 UPC 和 UCCr 检测。主人对犬在 AH、运输途中和 IH 的应激程度进行评分。
与 AH 样本相比，IH 样本中的 UCCr 显著更高（P < .0001），但 UPC 在 AH 和 IH 尿液样本之间无显著差异（P =.14）。在所有样本和两种采集环境下，UCCr 与 UPC 均无显著相关性。运输时间和 IH 时间与 UCCr 或 UPC 的变化均无相关性。在 8 只存在边界性或显性蛋白尿的犬中，两种环境下 UPC 之间无显著差异，但 IH 样本中的 UCCr 显著更高。
与 AH 样本相比，在 IH 采集的尿液样本中测量的 UPC 并未升高。犬的 IH 样本中 UCCr 更高，但 UCCr 与 UPC 无关。应激，如通过 UCCr 评估，并未影响蛋白尿。需要进一步的证据来支持应激可能导致健康犬发生蛋白尿的说法。
