Beckwith Curt, Castonguay Breana Uhrig, Trezza Claudia, Bazerman Lauri, Patrick Rudy, Cates Alice, Olsen Halli, Kurth Ann, Liu Tao, Peterson James, Kuo Irene
The Miriam Hospital, Providence, RI, United States of America.
Brown University Alpert School of Medicine, Providence, RI, United States of America.
PLoS One. 2017 Jan 12;12(1):e0169078. doi: 10.1371/journal.pone.0169078. eCollection 2017.
HIV-infected individuals recently released from incarceration have suboptimal linkage and engagement in community HIV care. We conducted a study to evaluate an information and communication technology intervention to increase linkage to community care among HIV-infected persons recently involved in the criminal justice (CJ) system. Baseline characteristics including risk behaviors and HIV care indicators are reported and stratified by gender.
We recruited HIV-infected individuals in the District of Columbia jail and persons with a recent history of incarceration through community and street outreach. Participants completed a baseline computer-assisted personal interview regarding HIV care and antiretroviral treatment (ART) adherence, substance use, and sexual behaviors. CD4 and HIV plasma viral load testing were performed at baseline or obtained through medical records. Data were analyzed for the sample overall and stratified by gender.
Of 110 individuals, 70% were community-enrolled, mean age was 40 (SD = 10.5), 85% were Black, and 58% were male, 24% female, and 18% transgender women. Nearly half (47%) had condomless sex in the three months prior to incarceration. Although drug dependence and hazardous alcohol use were highly prevalent overall, transgender women were more likely to have participated in drug treatment than men and women (90%, 61%, and 50% respectively; p = 0.01). Prior to their most recent incarceration, 80% had an HIV provider and 91% had ever taken ART. Among those, only 51% reported ≥90% ART adherence. Fewer women (67%) had received HIV medications during their last incarceration compared to men (96%) and transgender women (95%; p = 0.001). Although neither was statistically significant, transgender women and men had higher proportions of baseline HIV viral suppression compared to women (80%, 69%, and 48.0% respectively, p>0.05); a higher proportion of women had a CD4 count ≤200 compared to men and transgender women (17%, 8% and 5% respectively; p>0.05).
In this study, HIV-infected persons with recent incarceration in Washington, DC reported important risk factors and co-morbidities, yet the majority had access to HIV care and ART prior to, during, and after incarceration. Self-reported ART adherence was sub-optimal, and while there were not statistically significant differences, CJ-involved women appeared to be at greatest risk of poor HIV outcomes.
Registered on ClinicalTrials.gov on 10/16/2012. Reference number: NCT01721226.
刚从监狱释放的艾滋病毒感染者在社区艾滋病毒护理中的联系和参与情况不理想。我们开展了一项研究,以评估一种信息通信技术干预措施,以增加近期参与刑事司法(CJ)系统的艾滋病毒感染者与社区护理的联系。报告了包括风险行为和艾滋病毒护理指标在内的基线特征,并按性别进行分层。
我们通过社区和街头宣传,在哥伦比亚特区监狱招募了艾滋病毒感染者以及近期有入狱史的人员。参与者完成了一项关于艾滋病毒护理和抗逆转录病毒治疗(ART)依从性、药物使用和性行为的基线计算机辅助个人访谈。在基线时进行了CD4和艾滋病毒血浆病毒载量检测,或通过病历获取相关数据。对总体样本以及按性别分层的数据进行了分析。
在110名个体中,70%为社区登记人员,平均年龄为40岁(标准差 = 10.5),85%为黑人,58%为男性,24%为女性,18%为变性女性。近一半(47%)在入狱前三个月有无保护性行为。尽管药物依赖和有害饮酒总体上非常普遍,但变性女性比男性和女性更有可能参与过药物治疗(分别为90%、61%和50%;p = 0.01)。在最近一次入狱之前,80%有艾滋病毒治疗提供者,91%曾接受过抗逆转录病毒治疗。在这些人中,只有51%报告抗逆转录病毒治疗依从性≥90%。与男性(96%)和变性女性(95%)相比,在最后一次入狱期间接受艾滋病毒药物治疗的女性较少(67%;p = 0.001)。尽管两者均无统计学意义,但与女性相比,变性女性和男性的基线艾滋病毒病毒抑制比例更高(分别为80%、69%和48.0%,p>0.05);与男性和变性女性相比,CD4计数≤200的女性比例更高(分别为17%、8%和5%;p>0.05)。
在本研究中,华盛顿特区近期入狱的艾滋病毒感染者报告了重要的风险因素和合并症,但大多数人在入狱前、入狱期间和出狱后都能获得艾滋病毒护理和抗逆转录病毒治疗。自我报告的抗逆转录病毒治疗依从性不理想,虽然没有统计学上的显著差异,但参与刑事司法系统的女性似乎艾滋病毒预后不良的风险最大。
于2012年10月16日在ClinicalTrials.gov上注册。注册号:NCT01721226。