使用先进的混合闭环胰岛素输送系统的 1 型糖尿病患儿和青少年的患者报告结局测量。
Patient reported outcome measures in children and adolescents with type 1 diabetes using advanced hybrid closed loop insulin delivery.
机构信息
Department of Pediatric Endocrinology, Diabetes and Metabolic Diseases, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Slovenia and Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
出版信息
Front Endocrinol (Lausanne). 2022 Aug 19;13:967725. doi: 10.3389/fendo.2022.967725. eCollection 2022.
PURPOSE
To determine the impact of advanced hybrid closed - loop (AHCL) insulin delivery on quality of life, metabolic control and time in range (TIR) in youth with type 1 diabetes mellitus (T1DM).
METHODS
Twenty-four children and adolescents with T1DM (14 female) aged of 10 to 18 years participated in the study. Mixed methods study design was implemented. Quantitative part of the study was conducted as a longitudinal crossover study with data collection before and at the end of AHCL use. Qualitative data were obtained with modeled interviews of four focus groups before and the end of the period. Clinical data were collected from the electronic medical records.
RESULTS
The use of AHCL significantly improved the quality of life in terms of decreased fear of hypoglycemia (p<0.001), decrease in diabetes-related emotional distress (p<0.001), and increased wellbeing (p=0.003). The mean A1C decreased from 8.55 ± 1.34% (69.9 ± 12.3 mmol/mol) to 7.73 ± 0.42 (61.1 ± 2.2 mmol/mol) (p=0.002) at the end of the study. Mean TIR was 68.22% (± 13.89) before and 78.26 (± 6.29) % (p<0.001) at the end of the study.
CONCLUSION
The use of advanced hybrid closed loop significantly improved the quality of life and metabolic control in children and adolescents with T1DM.
目的
评估先进的混合闭环（AHCL）胰岛素输送对 1 型糖尿病（T1DM）青少年生活质量、代谢控制和血糖达标时间（TIR）的影响。
方法
本研究纳入了 24 名 10 至 18 岁的 T1DM 儿童和青少年（14 名女性），采用混合方法研究设计。研究采用纵向交叉设计，在使用 AHCL 之前和之后分别进行数据采集。定性数据通过 4 个焦点小组的模型访谈获得，访谈分别在使用 AHCL 之前和结束时进行。临床数据从电子病历中收集。
结果
AHCL 的使用显著改善了生活质量，表现在低血糖恐惧（p<0.001）、糖尿病相关情绪困扰（p<0.001）降低，以及幸福感增加（p=0.003）。研究结束时，糖化血红蛋白（A1C）均值从 8.55 ± 1.34%（69.9 ± 12.3 mmol/mol）降至 7.73 ± 0.42%（61.1 ± 2.2 mmol/mol）（p=0.002）。研究结束时，TIR 均值从 68.22%（± 13.89）提高至 78.26%（± 6.29）（p<0.001）。
结论
在 T1DM 青少年中使用先进的混合闭环系统可显著改善生活质量和代谢控制。
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