Wang Ke, Ren Yu, Liu Yang, Zhang Jian, He Jian-Jun
Department of Breast Surgery, the First Affiliated Hospital of Xian Jiaotong UniversityXianP.R. China.
Oncol Res. 2017 Jan 2;25(1):55-63. doi: 10.3727/096504016X14719078133320.
Tumor necrosis factor-α (TNF-α)-induced protein 8-like-2 (TNFAIP8L2 or TIPE2), a member of the tumor necrosis TNFAIP8 family, was found to be involved in the development and progression of several tumors. However, to date, the role of TIPE2 in breast cancer is still unclear. Thus, the aim of this study is to explore the role of TIPE2 in breast cancer. Our results indicated that TIPE2 expression was significantly decreased in human breast cancer tissue and cell lines. Overexpression of TIPE2 inhibited the proliferation in vitro and tumor xenograft growth in vivo. TIPE2 also inhibited the migration/invasion of breast cancer cells through preventing the epithelial-to-mesenchymal transition (EMT) phenotype. Mechanically, TIPE2 inhibited the expression of β-catenin, cyclin D1, and c-Myc in breast cancer cells. In conclusion, our findings show that TIPE2 may play an important role in breast cancer cell proliferation, invasion, and tumorigenesis in vivo. Therefore, TIPE2 may be a potential molecular target for the treatment of breast cancer.
肿瘤坏死因子-α（TNF-α）诱导蛋白8样蛋白2（TNFAIP8L2或TIPE2）是肿瘤坏死因子α诱导蛋白8（TNFAIP8）家族的成员之一，已发现其与多种肿瘤的发生发展有关。然而，迄今为止，TIPE2在乳腺癌中的作用仍不清楚。因此，本研究旨在探讨TIPE2在乳腺癌中的作用。我们的结果表明，TIPE2在人乳腺癌组织和细胞系中的表达显著降低。TIPE2的过表达抑制了体外增殖和体内肿瘤异种移植的生长。TIPE2还通过阻止上皮-间质转化（EMT）表型来抑制乳腺癌细胞的迁移/侵袭。机制上，TIPE2抑制乳腺癌细胞中β-连环蛋白、细胞周期蛋白D1和c-Myc的表达。总之，我们的研究结果表明，TIPE2可能在乳腺癌细胞增殖、侵袭及体内肿瘤发生中起重要作用。因此，TIPE2可能是治疗乳腺癌的潜在分子靶点。
