Liu Tingting, Li Qing, Xu Xu, Li Guoxia, Tian Chengwang, Zhang Tiejun
School of Basic Medicine, Tianjin Medical University, Tianjin 300070, China.
Tianjin Pharmaceutical Research Institute, Tianjin 300462, China.
Chin Herb Med. 2022 May 13;14(4):528-534. doi: 10.1016/j.chmed.2022.02.003. eCollection 2022 Oct.
Seaweed is a traditional Chinese medicine homologous to food, in which polysaccharides are responsible for anti-cancer by enhancing immunity, inducing cancer cell apoptosis, inhibiting cancer cell invasion and metastasis or directly scavenging oxidative free radicals that induce cancer cell changes. Among them, regulating immunity and promoting cancer cell apoptosis are intensively studied due to the important role in preventing cancer. Here we reviewed seaweed in the apoptosis-inducing signaling pathways including PI3K/AKT, ROS and JNK and discussed challenges in studying seaweed.
海藻是一种药食同源的传统中药，其中的多糖可通过增强免疫力、诱导癌细胞凋亡、抑制癌细胞侵袭和转移或直接清除诱导癌细胞变化的氧化自由基来发挥抗癌作用。其中，由于在预防癌症中发挥重要作用，调节免疫力和促进癌细胞凋亡受到了深入研究。在此，我们综述了海藻在包括PI3K/AKT、ROS和JNK在内的凋亡诱导信号通路中的作用，并讨论了海藻研究中的挑战。
