• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

沉默含犰狳重复序列蛋白8（ARMc8）可抑制转化生长因子-β（TGF-β）诱导的膀胱癌细胞UMUC3的上皮-间质转化。

Silencing of Armadillo Repeat-Containing Protein 8 (ARMc8) Inhibits TGF-β-Induced EMT in Bladder Carcinoma UMUC3 Cells.

作者信息

Liang Xuan, Men Qun-Li, Li Yong-Wei, Li He-Cheng, Chong Tie, Li Zhao-Lun

机构信息

Department of Oncology, The First Affiliated Hospital, Xian Jiaotong University Medical CollegeXian, ShaanxiP.R. China.

Department of Urology, The Central Hospital of BaojiBaoji, ShaanxiP.R. China.

出版信息

Oncol Res. 2017 Jan 2;25(1):99-105. doi: 10.3727/096504016X14719078133609.

DOI:10.3727/096504016X14719078133609
PMID:28081738
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7840676/
Abstract

Armadillo repeat-containing protein 8 (ARMc8) is a key factor in regulating cell migration, proliferation, tissue maintenance, and tumorigenesis. However, its role in bladder cancer remains unknown. Thus, in this study we sought to investigate the effect of ARMc8 on the epithelial-to-mesenchymal transition (EMT) progress in bladder cancer cells induced by transforming growth factor-β1 (TGF-β1). Our results found that ARMc8 was highly expressed in bladder cancer cell lines. ARMc8 silencing inhibited the TGF-β1-induced migration and invasion and suppressed the EMT progress in bladder cancer cells. Furthermore, ARMc8 silencing inhibited the TGF-β1-induced expression of β-catenin, cyclin D1, and c-myc in bladder cancer cells. In conclusion, the present study demonstrates a novel function for ARMc8, which acts as a mediator for TGF-β1-induced cell migration/invasion through modulation of the Wnt/β-catenin signaling pathway in bladder cancer cells. This study suggests that ARMc8 may be a potential therapeutic target for the development of therapies for bladder cancer.

摘要

含犰狳重复序列蛋白8（ARMc8）是调节细胞迁移、增殖、组织维持和肿瘤发生的关键因子。然而，其在膀胱癌中的作用尚不清楚。因此，在本研究中，我们试图探讨ARMc8对转化生长因子-β1（TGF-β1）诱导的膀胱癌细胞上皮-间质转化（EMT）进程的影响。我们的结果发现，ARMc8在膀胱癌细胞系中高表达。ARMc8沉默抑制了TGF-β1诱导的迁移和侵袭，并抑制了膀胱癌细胞的EMT进程。此外，ARMc8沉默抑制了TGF-β1诱导的膀胱癌细胞中β-连环蛋白、细胞周期蛋白D1和c-myc的表达。总之，本研究证明了ARMc8的一种新功能，它通过调节膀胱癌细胞中的Wnt/β-连环蛋白信号通路，作为TGF-β1诱导的细胞迁移/侵袭的介质。本研究表明，ARMc8可能是膀胱癌治疗开发的潜在治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e2/7840676/dc3849d22515/OR-25-099-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e2/7840676/000da603b286/OR-25-099-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e2/7840676/302acc8ba1c3/OR-25-099-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e2/7840676/b7fa71475572/OR-25-099-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e2/7840676/dc3849d22515/OR-25-099-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e2/7840676/000da603b286/OR-25-099-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e2/7840676/302acc8ba1c3/OR-25-099-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e2/7840676/b7fa71475572/OR-25-099-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e2/7840676/dc3849d22515/OR-25-099-g004.jpg

相似文献

1
Silencing of Armadillo Repeat-Containing Protein 8 (ARMc8) Inhibits TGF-β-Induced EMT in Bladder Carcinoma UMUC3 Cells.沉默含犰狳重复序列蛋白8（ARMc8）可抑制转化生长因子-β（TGF-β）诱导的膀胱癌细胞UMUC3的上皮-间质转化。
Oncol Res. 2017 Jan 2;25(1):99-105. doi: 10.3727/096504016X14719078133609.
2
Armadillo Repeat-Containing Protein 8 (ARMC8) Silencing Inhibits Proliferation and Invasion in Osteosarcoma Cells.含犰狳重复序列蛋白8（ARMC8）沉默抑制骨肉瘤细胞的增殖和侵袭
Oncol Res. 2016;24(5):381-389. doi: 10.3727/096504016X14685034103392.
3
Downregulation of ARMC8 promotes tumorigenesis through activating Wnt/β-catenin pathway and EMT in cutaneous squamous cell carcinomas.ARMC8 的下调通过激活 Wnt/β-catenin 通路和 EMT 促进皮肤鳞状细胞癌的发生。
J Dermatol Sci. 2021 Jun;102(3):184-192. doi: 10.1016/j.jdermsci.2021.05.002. Epub 2021 May 10.
4
MiR-455-3p inhibits gastric cancer progression by repressing Wnt/β-catenin signaling through binding to ARMC8.miR-455-3p 通过与 ARMC8 结合抑制 Wnt/β-catenin 信号通路从而抑制胃癌进展。
BMC Med Genomics. 2023 Jul 3;16(1):155. doi: 10.1186/s12920-023-01583-y.
5
ARMC8α promotes proliferation and invasion of non-small cell lung cancer cells by activating the canonical Wnt signaling pathway.ARMC8α通过激活经典Wnt信号通路促进非小细胞肺癌细胞的增殖和侵袭。
Tumour Biol. 2014 Sep;35(9):8903-11. doi: 10.1007/s13277-014-2162-z. Epub 2014 Jun 4.
6
GP73 promotes invasion and metastasis of bladder cancer by regulating the epithelial-mesenchymal transition through the TGF-β1/Smad2 signalling pathway.GP73 通过调节 TGF-β1/Smad2 信号通路促进膀胱癌的侵袭和转移。
J Cell Mol Med. 2018 Mar;22(3):1650-1665. doi: 10.1111/jcmm.13442. Epub 2018 Jan 19.
7
Silencing of HMGA2 suppresses cellular proliferation, migration, invasion, and epithelial-mesenchymal transition in bladder cancer.沉默HMGA2可抑制膀胱癌细胞的增殖、迁移、侵袭及上皮-间质转化。
Tumour Biol. 2016 Jun;37(6):7515-23. doi: 10.1007/s13277-015-4625-2. Epub 2015 Dec 18.
8
TGF-β1 dominates stromal fibroblast-mediated EMT via the FAP/VCAN axis in bladder cancer cells.TGF-β1 通过 FAP/VCAN 轴在膀胱癌细胞中主导基质成纤维细胞介导的 EMT。
J Transl Med. 2023 Jul 17;21(1):475. doi: 10.1186/s12967-023-04303-3.
9
HPIP silencing inhibits TGF-β1-induced EMT in lung cancer cells.HPIP基因沉默抑制肺癌细胞中转化生长因子-β1诱导的上皮-间质转化。
Int J Mol Med. 2017 Feb;39(2):479-483. doi: 10.3892/ijmm.2017.2851. Epub 2017 Jan 5.
10
Androgen receptor inducing bladder cancer progression by promoting an epithelial-mesenchymal transition.雄激素受体通过促进上皮-间质转化诱导膀胱癌进展。
Andrologia. 2014 Dec;46(10):1128-33. doi: 10.1111/and.12203. Epub 2013 Dec 16.

引用本文的文献

1
Comprehensive analysis of the expression and prognostic value of ARMCs in pancreatic adenocarcinoma.胰腺腺癌中ARMCs的表达及预后价值的综合分析
BMC Cancer. 2025 Jan 7;25(1):28. doi: 10.1186/s12885-024-13365-5.
2
MiR-455-3p inhibits gastric cancer progression by repressing Wnt/β-catenin signaling through binding to ARMC8.miR-455-3p 通过与 ARMC8 结合抑制 Wnt/β-catenin 信号通路从而抑制胃癌进展。
BMC Med Genomics. 2023 Jul 3;16(1):155. doi: 10.1186/s12920-023-01583-y.
3
Effects of the uremic toxin indoxyl sulphate on human microvascular endothelial cells.

本文引用的文献

1
Epigenetic disruption of the WNT/ß-catenin signaling pathway in human cancers.人类癌症中WNT/β-连环蛋白信号通路的表观遗传失调。
Epigenetics. 2009 Jul 1;4(5):307-312. doi: 10.4161/epi.4.5.9371.
2
ARMc8: a potential diagnostic and therapeutic target for cancers.
Hum Pathol. 2016 Aug;54:201. doi: 10.1016/j.humpath.2016.02.021. Epub 2016 Mar 29.
3
Armc8 regulates the invasive ability of hepatocellular carcinoma through E-cadherin/catenin complex.Armc8通过E-钙黏蛋白/连环蛋白复合体调节肝细胞癌的侵袭能力。
尿毒症毒素吲哚硫酸酯对人微血管内皮细胞的影响。
J Appl Toxicol. 2022 Dec;42(12):1948-1961. doi: 10.1002/jat.4366. Epub 2022 Jul 25.
4
The micro RNA hsa-miR-377-3p inhibits tumor growth in malignant melanoma.微小RNA hsa-miR-377-3p抑制恶性黑色素瘤的肿瘤生长。
RSC Adv. 2019 Jun 17;9(33):19057-19064. doi: 10.1039/c9ra02816a. eCollection 2019 Jun 14.
5
ARMC Subfamily: Structures, Functions, Evolutions, Interactions, and Diseases.ARMC亚家族：结构、功能、进化、相互作用及疾病
Front Mol Biosci. 2021 Nov 29;8:791597. doi: 10.3389/fmolb.2021.791597. eCollection 2021.
6
The human GID complex engages two independent modules for substrate recruitment.人类 GID 复合物结合两个独立的模块来募集底物。
EMBO Rep. 2021 Nov 4;22(11):e52981. doi: 10.15252/embr.202152981. Epub 2021 Oct 14.
7
The CTLH Complex in Cancer Cell Plasticity.癌细胞可塑性中的CTLH复合体
J Oncol. 2019 Nov 30;2019:4216750. doi: 10.1155/2019/4216750. eCollection 2019.
8
TGF-β and microRNA Interplay in Genitourinary Cancers.TGF-β 与泌尿生殖系统癌症中的 microRNA 相互作用。
Cells. 2019 Dec 12;8(12):1619. doi: 10.3390/cells8121619.
9
Clinicohistopathological implications of phosphoserine 9 glycogen synthase kinase-3β/ β-catenin in urinary bladder cancer patients.磷酸丝氨酸9糖原合酶激酶-3β/β-连环蛋白在膀胱癌患者中的临床组织病理学意义
World J Clin Oncol. 2019 Apr 24;10(4):166-182. doi: 10.5306/wjco.v10.i4.166.
10
Armc8 is an evolutionarily conserved armadillo protein involved in cell-cell adhesion complexes through multiple molecular interactions.Armc8 是一种进化上保守的锚蛋白重复序列结构域蛋白，通过多种分子相互作用参与细胞-细胞黏附复合物。
Biosci Rep. 2019 Aug 2;39(8). doi: 10.1042/BSR20180604. Print 2019 Aug 30.
Tumour Biol. 2016 Aug;37(8):11219-24. doi: 10.1007/s13277-016-5006-1. Epub 2016 Mar 4.
4
A novel biomarker ARMc8 promotes the malignant progression of ovarian cancer.一种新型生物标志物ARMc8促进卵巢癌的恶性进展。
Hum Pathol. 2015 Oct;46(10):1471-9. doi: 10.1016/j.humpath.2015.06.004. Epub 2015 Jun 16.
5
ARMc8 indicates aggressive colon cancers and promotes invasiveness and migration of colon cancer cells.ARMc8表明侵袭性结肠癌，并促进结肠癌细胞的侵袭和迁移。
Tumour Biol. 2015 Nov;36(11):9005-13. doi: 10.1007/s13277-015-3664-z. Epub 2015 Jun 18.
6
Prognostic and Prediction Tools in Bladder Cancer: A Comprehensive Review of the Literature.膀胱癌的预后和预测工具：文献综述。
Eur Urol. 2015 Aug;68(2):238-53. doi: 10.1016/j.eururo.2015.01.032. Epub 2015 Feb 21.
7
Global cancer statistics, 2012.全球癌症统计数据，2012 年。
CA Cancer J Clin. 2015 Mar;65(2):87-108. doi: 10.3322/caac.21262. Epub 2015 Feb 4.
8
Armc8 expression was elevated during atypia-to-carcinoma progression and associated with cancer development of breast carcinoma.在非典型增生向癌进展过程中，Armc8表达升高，且与乳腺癌的发生发展相关。
Tumour Biol. 2014 Nov;35(11):11337-43. doi: 10.1007/s13277-014-2473-0. Epub 2014 Aug 14.
9
ARMC8α promotes proliferation and invasion of non-small cell lung cancer cells by activating the canonical Wnt signaling pathway.ARMC8α通过激活经典Wnt信号通路促进非小细胞肺癌细胞的增殖和侵袭。
Tumour Biol. 2014 Sep;35(9):8903-11. doi: 10.1007/s13277-014-2162-z. Epub 2014 Jun 4.
10
Critical role of miR-10b in transforming growth factor-β1-induced epithelial-mesenchymal transition in breast cancer.miR-10b在转化生长因子-β1诱导的乳腺癌上皮-间质转化中的关键作用
Cancer Gene Ther. 2014 Feb;21(2):60-7. doi: 10.1038/cgt.2013.82. Epub 2014 Jan 24.