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标准桃金娘油肠溶胶囊是抗生素的新替代品吗?

Is Myrtol® Standardized a New Alternative toward Antibiotics?

作者信息

Paparoupa Maria, Gillissen Adrian

机构信息

Department of Pulmonary Diseases, Klinikum Kassel, University Hospital of Southampton, Mönchebergstrasse 41-43, D-35125 Kassel, Germany.

出版信息

Pharmacogn Rev. 2016 Jul-Dec;10(20):143-146. doi: 10.4103/0973-7847.194045.

DOI:10.4103/0973-7847.194045
PMID:28082798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5214559/
Abstract

GeloMyrtol and GeloMyrtol forte, also known as Myrtol standardized, is an herbal medical product (phytomedicine) obtained by a multistep distillation procedure from essential oils. The major biological marker of and activity of Myrtol standardized is the monoterpenes, d-limonene, 1,8-cineole, and alpha-pinene. Myrtol standardized is estimated to have antioxidative, anti-inflammatory, and antibacterial potential while many studies confirmed its secretolytic and bronchospasmolytic effects. As such, the medication is proposed to be initiated in several acute and chronic infections of the upper and lower airway system as acute and chronic rhinosinusitis, acute and chronic bronchitis, and chronic obstructive pulmonary disease. This review intends to give an insight into several prescription indications of Myrtol standardized, all involved mechanisms, and potential advantages toward antibiotic therapy, especially in cases when bacterial infection is uncertain.

摘要

吉诺通和强力吉诺通,也被称为标准桃金娘油,是一种通过多步蒸馏程序从精油中提取的草药产品(植物药)。标准桃金娘油活性的主要生物标志物是单萜类化合物、d-柠檬烯、1,8-桉叶素和α-蒎烯。据估计,标准桃金娘油具有抗氧化、抗炎和抗菌潜力,同时许多研究证实了其化痰和解支气管痉挛的作用。因此,该药物被建议用于上、下气道系统的多种急慢性感染,如急慢性鼻窦炎、急慢性支气管炎和慢性阻塞性肺疾病。本综述旨在深入探讨标准桃金娘油的几种处方适应症、所有相关机制以及相对于抗生素治疗的潜在优势,特别是在细菌感染情况不明的病例中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c101/5214559/3af042c4c086/PRev-10-143-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c101/5214559/f1be1ee69892/PRev-10-143-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c101/5214559/3af042c4c086/PRev-10-143-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c101/5214559/f1be1ee69892/PRev-10-143-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c101/5214559/3af042c4c086/PRev-10-143-g002.jpg

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本文引用的文献

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Continued high rates of antibiotic prescribing to adults with respiratory tract infection: survey of 568 UK general practices.对英国568家全科诊所的调查:成人呼吸道感染抗生素处方率持续居高不下
BMJ Open. 2014 Oct 27;4(10):e006245. doi: 10.1136/bmjopen-2014-006245.
2
Acute sinusitis and pharyngitis as inappropriate indications for antibiotic use.急性鼻窦炎和咽炎作为不恰当的抗生素使用指征。
Antimicrob Agents Chemother. 2014 Jun;58(6):3572. doi: 10.1128/AAC.02696-14.
3
[Clinical study of decoction of invigorating Qi and clearing lung combined standardized myrtol on acute exacerbation of chronic obstructive pulmonary disease (AECOPD)].
一种治疗急性病毒性鼻-鼻窦炎的草药配方。
Turk Arch Otorhinolaryngol. 2021 Mar;59(1):33-42. doi: 10.4274/tao.2020.6098. Epub 2021 Mar 26.
4
Appropriate use of essential oils and their components in the management of upper respiratory tract symptoms in patients with COVID-19.新冠病毒病患者上呼吸道症状管理中精油及其成分的合理应用
J Herb Med. 2021 Aug;28:100451. doi: 10.1016/j.hermed.2021.100451. Epub 2021 Mar 26.
益气清肺汤联合标准桃金娘油治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床研究
Zhongguo Zhong Yao Za Zhi. 2013 Feb;38(3):440-2.
4
A multi-centre, randomised, double-blind, placebo-controlled clinical trial on the efficacy and tolerability of GeloMyrtol® forte in acute bronchitis.一项关于强力吉诺通®治疗急性支气管炎疗效和耐受性的多中心、随机、双盲、安慰剂对照临床试验。
Drug Res (Stuttg). 2013 Jan;63(1):19-27. doi: 10.1055/s-0032-1331182. Epub 2013 Jan 8.
5
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Adv Ther. 2012 Apr;29(4):350-8. doi: 10.1007/s12325-012-0014-z. Epub 2012 Apr 2.
6
IDSA clinical practice guideline for acute bacterial rhinosinusitis in children and adults.美国感染病学会临床实践指南:儿童和成人急性细菌性鼻-鼻窦炎。
Clin Infect Dis. 2012 Apr;54(8):e72-e112. doi: 10.1093/cid/cir1043. Epub 2012 Mar 20.
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Anti-inflammatory effects of Myrtol standardized and other essential oils on alveolar macrophages from patients with chronic obstructive pulmonary disease.标准化桃金娘油和其他精油对慢性阻塞性肺疾病患者肺泡巨噬细胞的抗炎作用。
Eur J Med Res. 2009 Dec 7;14 Suppl 4(Suppl 4):205-9. doi: 10.1186/2047-783x-14-s4-205.
9
The effect of myrtol standardized on human nasal ciliary beat frequency and mucociliary transport time.标准化桃金娘醇对人鼻纤毛摆动频率和黏液纤毛传输时间的影响。
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Otolaryngol Head Neck Surg. 2007 Oct;137(4):555-61. doi: 10.1016/j.otohns.2007.02.004.