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Comparison of Three Non-Invasive Transcranial Electrical Stimulation Methods for Increasing Cortical Excitability.

作者信息

Inukai Yasuto, Saito Kei, Sasaki Ryoki, Tsuiki Shota, Miyaguchi Shota, Kojima Sho, Masaki Mitsuhiro, Otsuru Naofumi, Onishi Hideaki

机构信息

Department of Physical Therapy, Niigata University of Health and WelfareNiigata, Japan; Institute for Human Movement and Medical Sciences, Niigata University of Health and WelfareNiigata, Japan.

Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare Niigata, Japan.

出版信息

Front Hum Neurosci. 2016 Dec 27;10:668. doi: 10.3389/fnhum.2016.00668. eCollection 2016.


DOI:10.3389/fnhum.2016.00668
PMID:28082887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5186778/
Abstract

Transcranial direct current stimulation (tDCS) is a representative non-invasive brain stimulation method (NIBS). tDCS increases cortical excitability not only in healthy individuals, but also in stroke patients where it contributes to motor function improvement. Recently, two additional types of transcranial electrical stimulation (tES) methods have been introduced that may also prove beneficial for stimulating cortical excitability; these are transcranial random noise stimulation (tRNS) and transcranial alternating current stimulation (tACS). However, comparison of tDCS with tRNS and tACS, in terms of efficacy in cortical excitability alteration, has not been reported thus far. We compared the efficacy of the three different tES methods for increasing cortical excitability using the same subject population and same current intensity. Fifteen healthy subjects participated in this study. Similar stimulation patterns (1.0 mA and 10 min) were used for the three conditions of stimulation (tDCS, tRNS, and tACS). Cortical excitability was explored via single-pulse TMS elicited motor evoked potentials (MEPs). Compared with pre-measurements, MEPs significantly increased with tDCS, tACS, and tRNS ( < 0.05). Compared with sham measurements, significant increases in MEPs were also observed with tRNS and tACS ( < 0.05), but not with tDCS. In addition, a significant correlation of the mean stimulation effect was observed between tRNS and tACS ( = 0.019, = 0.598). tRNS induced a significant increase in MEP compared with the Pre or Sham at all time points. tRNS resulted in the largest significant increase in MEPs. These findings suggest that tRNS is the most effective tES method and should be considered as part of a treatment plan for improving motor function in stroke patients.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dad/5186778/1eb6e8f337bc/fnhum-10-00668-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dad/5186778/1718bae54375/fnhum-10-00668-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dad/5186778/deaf6096a253/fnhum-10-00668-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dad/5186778/a5a934ef2751/fnhum-10-00668-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dad/5186778/1eb6e8f337bc/fnhum-10-00668-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dad/5186778/1718bae54375/fnhum-10-00668-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dad/5186778/deaf6096a253/fnhum-10-00668-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dad/5186778/a5a934ef2751/fnhum-10-00668-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dad/5186778/1eb6e8f337bc/fnhum-10-00668-g0004.jpg

相似文献

[1]
Comparison of Three Non-Invasive Transcranial Electrical Stimulation Methods for Increasing Cortical Excitability.

Front Hum Neurosci. 2016-12-27

[2]
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[3]
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[4]
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[5]
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Physiol Rep. 2020-10

[6]
Comparison of the effects of transcranial random noise stimulation and transcranial direct current stimulation on motor cortical excitability.

J ECT. 2015-3

[7]
The Effects of 1 mA tACS and tRNS on Children/Adolescents and Adults: Investigating Age and Sensitivity to Sham Stimulation.

Neural Plast. 2020

[8]
Does transcranial electrical stimulation enhance corticospinal excitability of the motor cortex in healthy individuals? A systematic review and meta-analysis.

Eur J Neurosci. 2017-8-2

[9]
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[10]
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引用本文的文献

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[2]
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[3]
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[4]
No evidence of improvements in inhibitory control with tRNS.

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[5]
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[6]
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[7]
The effect of transcranial random noise stimulation (tRNS) over bilateral parietal cortex in visual cross-modal conflicts.

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[8]
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Sci Rep. 2025-2-3

[9]
Dissociable components of visual perceptual learning characterized by non-invasive brain stimulation: Stage 1 Registered Report.

Brain Commun. 2025-1-2

[10]
Anodal transcranial direct current stimulation (tDCS) modulates quadriceps motor cortex inhibition and facilitation during rehabilitation following anterior cruciate ligament (ACL) reconstruction: a triple-blind, randomised controlled proof of concept trial.

BMJ Open Sport Exerc Med. 2024-12-9

本文引用的文献

[1]
Transcranial Alternating Current and Random Noise Stimulation: Possible Mechanisms.

Neural Plast. 2016

[2]
Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain.

Nat Commun. 2016-3-22

[3]
Transcranial direct current stimulation (tDCS) for improving activities of daily living, and physical and cognitive functioning, in people after stroke.

Cochrane Database Syst Rev. 2016-3-21

[4]
Transcranial Direct Current Stimulation Post-Stroke Upper Extremity Motor Recovery Studies Exhibit a Dose-Response Relationship.

Brain Stimul. 2016

[5]
Duration-dependent effects of the BDNF Val66Met polymorphism on anodal tDCS induced motor cortex plasticity in older adults: a group and individual perspective.

Front Aging Neurosci. 2015-6-5

[6]
The contribution of interindividual factors to variability of response in transcranial direct current stimulation studies.

Front Cell Neurosci. 2015-5-12

[7]
Transcranial random noise stimulation-induced plasticity is NMDA-receptor independent but sodium-channel blocker and benzodiazepines sensitive.

Front Neurosci. 2015-4-10

[8]
Determinants of the electric field during transcranial direct current stimulation.

Neuroimage. 2015-1-19

[9]
Comparing the efficacy of excitatory transcranial stimulation methods measuring motor evoked potentials.

Neural Plast. 2014-4-3

[10]
Inter-individual variability in response to non-invasive brain stimulation paradigms.

Brain Stimul. 2014

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