Ho Kerrie-Anne, Taylor Janet L, Loo Colleen K
From the *School of Psychiatry, University of New South Wales, Black Dog Institute, †Neuroscience Research Australia and School of Medical Sciences, University of New South Wales, and ‡Department of Psychiatry, St George Hospital, Sydney, Australia.
J ECT. 2015 Mar;31(1):67-72. doi: 10.1097/YCT.0000000000000155.
The objective of this study was to examine the effect of transcranial random noise stimulation (tRNS) with and without a direct current (DC) offset on motor cortical excitability and compare results to transcranial DC stimulation (tDCS).
Fifteen healthy participants were tested in a within-subjects design. Motor-evoked potentials were measured before and up to 90 minutes after stimulation using transcranial magnetic stimulation. Five stimulation conditions were examined: sham, 1-mA tDCS, 2-mA tDCS, 2-mA tRNS (with no DC offset), and 2-mA tRNS + 1-mA DC offset.
There were no significant differences between the stimulation conditions. An analysis of individual stimulation conditions found that there was a significant increase in motor-evoked potential amplitudes after 1-mA tDCS, 2-mA tDCS, and 2-mA tRNS + DC offset when compared with baseline. Sham and 2-mA tRNS did not result in changes in cortical excitability.
Although differences between the stimulation conditions did not reach a statistical significance, the findings suggest that stimulation involving a DC (tDCS and tRNS + DC offset) but not solely tRNS is more likely to lead to increases in cortical excitability.
本研究的目的是检验有无直流偏移的经颅随机噪声刺激（tRNS）对运动皮质兴奋性的影响，并将结果与经颅直流电刺激（tDCS）进行比较。
15名健康参与者采用受试者内设计进行测试。使用经颅磁刺激在刺激前及刺激后长达90分钟测量运动诱发电位。检查了五种刺激条件：假刺激、1毫安tDCS、2毫安tDCS、2毫安tRNS（无直流偏移）和2毫安tRNS + 1毫安直流偏移。
刺激条件之间无显著差异。对个体刺激条件的分析发现，与基线相比，1毫安tDCS、2毫安tDCS和2毫安tRNS + 直流偏移后运动诱发电位幅度显著增加。假刺激和2毫安tRNS未导致皮质兴奋性改变。
虽然刺激条件之间的差异未达到统计学显著性，但研究结果表明，涉及直流电的刺激（tDCS和tRNS + 直流偏移）而非单纯的tRNS更有可能导致皮质兴奋性增加。
