葡萄糖对布氏毛霉中异柠檬酸裂解酶的影响。
Effect of glucose on isocitrate lyase in Phycomyces blakesleeanus.
作者信息
Rua J, De Arriaga D, Busto F, Soler J
机构信息
Departamento de Bioquímica y Biología Molecular, Universidad de León, Spain.
出版信息
J Bacteriol. 1989 Nov;171(11):6391-3. doi: 10.1128/jb.171.11.6391-6393.1989.
Abstract
Repression of the synthesis of isocitrate lyase by glucose and/or induction of the synthesis of isocitrate lyase by acetate in Phycomyces blakesleeanus were demonstrated. Both glycerol and ethanol failed to induce isocitrate lyase activity. Furthermore, glucose appeared to cause an in vivo catabolite inactivation of the derepressed enzyme. Isocitrate lyase was inactivated both reversibly and irreversibly by glucose.
摘要
已证明在布氏梨形孢中，葡萄糖会抑制异柠檬酸裂解酶的合成，而乙酸盐会诱导异柠檬酸裂解酶的合成。甘油和乙醇均不能诱导异柠檬酸裂解酶的活性。此外，葡萄糖似乎会导致去阻遏酶在体内发生分解代谢失活。葡萄糖会使异柠檬酸裂解酶发生可逆和不可逆的失活。
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