de Souza Livia Victorino, Oliveira Vanessa, Laurindo Aline Oliveira, Huarachı DelmaRegına Gomes, Nogueira Paulo Cesar Koch, Feltran Luciana de Santis, Medina-Pestana José Osmar, Franco Maria do Carmo
Nephrology Division, School of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil.
Pediatrics Department, School of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil.
Int J Nephrol. 2016;2016:2180765. doi: 10.1155/2016/2180765. Epub 2016 Dec 19.
Endocan is an important biomarker of inflammation and endothelial dysfunction that increases in association with several chronic diseases. Few published data have described the role of endocan in pediatric renal transplant (RT) patients. We evaluated the endocan concentrations in 62 children who underwent renal transplantation and assessed their relationships with the patients' blood pressure and loss of renal function. The endocan levels were significantly elevated in the pediatric RT patients who had hypertension and a loss of renal function. We determined positive correlations between the endocan concentrations and the hemodynamic variables (systolic blood pressure: = 0.416; = 0.001; pulse pressure: = 0.412; = 0.003). The endocan levels were inversely correlated with the estimated glomerular filtration rate ( = -0.388; = 0.003). An endocan cutoff concentration of 7.0 ng/mL identified pediatric RT patients who had hypertension and a loss of renal function with 100% sensitivity and 75% specificity. In conclusion, the endocan concentrations were significantly elevated in pediatric RT patients who had both hypertension and a loss of renal function. The correlations between the endocan levels and the hemodynamic variables and the markers of renal function strengthen the hypothesis that it is an important marker of cardiorenal risk.
内脂素是炎症和内皮功能障碍的重要生物标志物，其水平会随着多种慢性疾病而升高。很少有已发表的数据描述内脂素在小儿肾移植（RT）患者中的作用。我们评估了62例接受肾移植的儿童的内脂素浓度，并评估了其与患者血压和肾功能丧失之间的关系。高血压和肾功能丧失的小儿RT患者的内脂素水平显著升高。我们确定了内脂素浓度与血流动力学变量之间的正相关性（收缩压：= 0.416；= 0.001；脉压：= 0.412；= 0.003）。内脂素水平与估计的肾小球滤过率呈负相关（= -0.388；= 0.003）。内脂素临界浓度为7.0 ng/mL时，可100%敏感且75%特异度地识别出患有高血压和肾功能丧失的小儿RT患者。总之，高血压和肾功能丧失的小儿RT患者的内脂素浓度显著升高。内脂素水平与血流动力学变量和肾功能标志物之间的相关性强化了以下假设：它是心肾风险的重要标志物。
