Chen Qiaozhen, Zhang Ying, Hou Haifeng, Du Fenglei, Wu Shuang, Chen Lin, Shen Yehua, Chao Fangfang, Chung June-Key, Zhang Hong, Tian Mei
Department of Psychiatry, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Zhejiang University Medical PET Center, Hangzhou, China.
Eur J Nucl Med Mol Imaging. 2017 Jun;44(6):1033-1041. doi: 10.1007/s00259-017-3614-7. Epub 2017 Jan 12.
Music can induce different emotions. However, its neural mechanism remains unknown. The aim of this study was to use functional magnetic resonance imaging (fMRI) and position emission tomography (PET) imaging for mapping of neural changes under the most popular music in healthy volunteers.
Blood-oxygen-level-dependent (BOLD) fMRI and monoamine receptor PET imaging with C-N-methylspiperone (C-NMSP) were conducted under the popular music Gangnam Style and light music A Comme Amour in healthy subjects. PET and fMRI images were analyzed by using the Statistical Parametric Mapping software (SPM).
Significantly increased fMRI BOLD signals were found in the bilateral superior temporal cortices, left cerebellum, left putamen and right thalamus cortex. Monoamine receptor availability was increased significantly in the left superior temporal gyrus and left putamen, but decreased in the bilateral superior occipital cortices under the Gangnam Style compared with the light music condition. Significant positive correlation was found between C-NMSP binding and fMRI BOLD signals in the left temporal cortex. Furthermore, increased C-NMSP binding in the left putamen was positively correlated with the mood arousal level score under the Gangnam Style condition.
Popular music Gangnam Style can arouse pleasure experience and strong emotional response. The left putamen is positively correlated with the mood arousal level score under the Gangnam Style condition. Our results revealed characteristic patterns of brain activity associated with Gangnam Style, and may also provide more general insights into the music-induced emotional processing.
音乐能够诱发不同的情绪。然而，其神经机制尚不清楚。本研究旨在利用功能磁共振成像（fMRI）和正电子发射断层扫描（PET）成像技术，绘制健康志愿者在最流行音乐刺激下的神经变化图谱。
在健康受试者中，于流行音乐《江南Style》和轻音乐《秋日私语》的刺激下，进行血氧水平依赖性功能磁共振成像（BOLD-fMRI）以及使用碳-氮-甲基螺哌隆（C-NMSP）的单胺受体PET成像。采用统计参数映射软件（SPM）对PET和fMRI图像进行分析。
在双侧颞上叶皮质、左侧小脑、左侧壳核和右侧丘脑皮质中发现fMRI的BOLD信号显著增加。与轻音乐条件相比，在《江南Style》刺激下，左侧颞上回和左侧壳核的单胺受体可用性显著增加，但双侧枕叶皮质的单胺受体可用性降低。在左侧颞叶皮质中，发现C-NMSP结合与fMRI的BOLD信号之间存在显著正相关。此外，在《江南Style》条件下，左侧壳核中C-NMSP结合的增加与情绪唤醒水平得分呈正相关。
流行音乐《江南Style》能够唤起愉悦体验和强烈的情绪反应。在《江南Style》条件下，左侧壳核与情绪唤醒水平得分呈正相关。我们的研究结果揭示了与《江南Style》相关的大脑活动特征模式，也可能为音乐诱发的情绪加工提供更普遍的见解。
