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药理学精准医学中的影像学技术。

Imaging Techniques in Pharmacological Precision Medicine.

机构信息

Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University of Tübingen, Tübingen, Germany.

Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies," University of Tübingen, Tübingen, Germany.

出版信息

Handb Exp Pharmacol. 2023;280:213-235. doi: 10.1007/164_2023_641.

Abstract

Biomedical imaging is a powerful tool for medical diagnostics and personalized medicines. Examples of commonly used imaging modalities include Positron Emission Tomography (PET), Ultrasound (US), Single Photon Emission Computed Tomography (SPECT), and hybrid imaging. By combining these modalities, scientists can gain a comprehensive view and better understand physiology and pathology at the preclinical, clinical, and multiscale levels. This can aid in the accuracy of medical diagnoses and treatment decisions. Moreover, biomedical imaging allows for evaluating the metabolic, functional, and structural details of living tissues. This can be particularly useful for the early diagnosis of diseases such as cancer and for the application of personalized medicines. In the case of hybrid imaging, two or more modalities are combined to produce a high-resolution image with enhanced sensitivity and specificity. This can significantly improve the accuracy of diagnosis and offer more detailed treatment plans. In this book chapter, we showcase how continued advancements in biomedical imaging technology can potentially revolutionize medical diagnostics and personalized medicine.

摘要

生物医学成像是医学诊断和个性化医疗的有力工具。常用的成像方式包括正电子发射断层扫描(PET)、超声(US)、单光子发射计算机断层扫描(SPECT)和混合成像。通过结合这些方式,科学家可以在临床前、临床和多尺度水平上获得全面的观察,并更好地理解生理学和病理学。这有助于提高医学诊断和治疗决策的准确性。此外,生物医学成像可以评估活组织的代谢、功能和结构细节。这对于癌症等疾病的早期诊断和个性化药物的应用特别有用。在混合成像中,两种或更多种方式结合使用,以产生具有更高灵敏度和特异性的高分辨率图像。这可以显著提高诊断的准确性,并提供更详细的治疗计划。在本章中,我们展示了生物医学成像技术的持续进步如何有可能彻底改变医学诊断和个性化医疗。

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