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Will cancer cells be defeated by sodium bicarbonate?癌细胞会被碳酸氢钠打败吗？
Sci China Life Sci. 2017 Mar;60(3):326-328. doi: 10.1007/s11427-016-0373-3. Epub 2017 Jan 4.
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NBCn1 (slc4a7) mediates the Na+-dependent bicarbonate transport important for regulation of intracellular pH in mouse vascular smooth muscle cells.NBCn1（溶质载体家族4成员7）介导对小鼠血管平滑肌细胞内pH调节至关重要的钠依赖性碳酸氢盐转运。
Circ Res. 2006 Mar 3;98(4):515-23. doi: 10.1161/01.RES.0000204750.04971.76. Epub 2006 Jan 26.
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[Precipitation of pH-adjusted local anesthetics with sodium bicarbonate].[用碳酸氢钠沉淀pH值调整后的局部麻醉剂]
Masui. 1995 Jan;44(1):15-20.
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Standard versus pH-adjusted and lidocaine supplemented radiocolloid for patients undergoing sentinel-lymph-node mapping and biopsy for early breast cancer (PASSION-P trial): a double-blind, randomised controlled trial.标准放射性胶体与pH值调整及利多卡因补充的放射性胶体用于早期乳腺癌前哨淋巴结定位和活检患者的比较（PASSION-P试验）：一项双盲、随机对照试验。
Lancet Oncol. 2009 Sep;10(9):849-54. doi: 10.1016/S1470-2045(09)70194-9. Epub 2009 Aug 5.
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Grocery store baking soda. A source of sodium bicarbonate in the management of chronic metabolic acidosis.杂货店小苏打。慢性代谢性酸中毒管理中碳酸氢钠的一个来源。
Clin Pediatr (Phila). 1984 Feb;23(2):94-6. doi: 10.1177/000992288402300205.
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Effect of interval between doses on response of the pony to sodium bicarbonate.给药间隔对小马驹对碳酸氢钠反应的影响。
Cornell Vet. 1991 Jan;81(1):59-66.
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Bicarbonate/chloride antiport in Vero cells: I. Evidence for both sodium-linked and sodium-independent exchange.非洲绿猴肾细胞中的碳酸氢根/氯离子反向转运：I. 钠偶联和非钠偶联交换的证据
J Cell Physiol. 1987 Aug;132(2):183-91. doi: 10.1002/jcp.1041320202.
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Adaptation of HCO-3 and NH+4 transport in rat MTAL: effects of chronic metabolic acidosis and Na+ intake.大鼠髓袢升支粗段中HCO-3和NH+4转运的适应性：慢性代谢性酸中毒和钠摄入的影响
Am J Physiol. 1990 May;258(5 Pt 2):F1345-53. doi: 10.1152/ajprenal.1990.258.5.F1345.
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Effect of PO2 and metabolic inhibitors on ionic fluxes across the isolated rabbit corneal endothelium.氧分压和代谢抑制剂对离体兔角膜内皮细胞离子通量的影响。
Lens Eye Toxic Res. 1990;7(2):103-19.
引用本文的文献
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Redox Regulation of Phosphatase and Tensin Homolog by Bicarbonate and Hydrogen Peroxide: Implication of Peroxymonocarbonate in Cell Signaling.碳酸氢盐和过氧化氢对磷酸酶与张力蛋白同源物的氧化还原调节：过氧一碳酸酯在细胞信号传导中的作用
Antioxidants (Basel). 2024 Apr 17;13(4):473. doi: 10.3390/antiox13040473.
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Intracellular marriage of bicarbonate and Mn ions as "immune ion reactors" to regulate redox homeostasis and enhanced antitumor immune responses.碳酸氢根离子和 Mn 离子的细胞内“婚姻”作为“免疫离子反应剂”，调节氧化还原稳态和增强抗肿瘤免疫反应。
J Nanobiotechnology. 2022 Apr 19;20(1):193. doi: 10.1186/s12951-022-01404-x.
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The H-ATPase (V-ATPase): from proton pump to signaling complex in health and disease.H-ATP 酶（V-ATP 酶）：在健康和疾病中的质子泵到信号复合物。
Am J Physiol Cell Physiol. 2021 Mar 1;320(3):C392-C414. doi: 10.1152/ajpcell.00442.2020. Epub 2020 Dec 16.
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Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H-Centered Anticancer Paradigm of the Late Post-Warburg Era.基于后沃伯格时代的新以 H 为中心的抗癌范式的乳腺癌整体治疗方案。
Int J Mol Sci. 2020 Oct 10;21(20):7475. doi: 10.3390/ijms21207475.
本文引用的文献
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A nonrandomized cohort and a randomized study of local control of large hepatocarcinoma by targeting intratumoral lactic acidosis.一项针对大肝癌瘤内乳酸酸中毒进行局部控制的非随机队列研究和随机研究。
Elife. 2016 Aug 2;5:e15691. doi: 10.7554/eLife.15691.
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The PD-1/PD-L1 axis contributes to immune metabolic dysfunctions of monocytes in chronic lymphocytic leukemia.PD-1/PD-L1 轴导致慢性淋巴细胞白血病中单核细胞的免疫代谢功能紊乱。
Leukemia. 2017 Feb;31(2):470-478. doi: 10.1038/leu.2016.214. Epub 2016 Aug 1.
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Safety and feasibility of fasting in combination with platinum-based chemotherapy.禁食联合铂类化疗的安全性与可行性
BMC Cancer. 2016 Jun 10;16:360. doi: 10.1186/s12885-016-2370-6.
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Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters.缺氧、癌症代谢与靶向乳酸/H(+) 同向转运体的治疗益处
J Mol Med (Berl). 2016 Feb;94(2):155-71. doi: 10.1007/s00109-015-1307-x. Epub 2015 Jun 24.
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Treatment of glioma patients with ketogenic diets: report of two cases treated with an IRB-approved energy-restricted ketogenic diet protocol and review of the literature.生酮饮食治疗脑胶质瘤患者：两例接受 IRB 批准的能量限制生酮饮食方案治疗的病例报告及文献复习。
Cancer Metab. 2015 Mar 25;3:3. doi: 10.1186/s40170-015-0129-1. eCollection 2015.
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131I-labeled metuximab combined with chemoembolization for unresectable hepatocellular carcinoma.131I 标记的美妥昔单抗联合化疗栓塞治疗不可切除的肝细胞癌。
World J Gastroenterol. 2013 Dec 21;19(47):9104-10. doi: 10.3748/wjg.v19.i47.9104.
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Tumor glycolysis as a target for cancer therapy: progress and prospects.肿瘤糖酵解作为癌症治疗的靶点：进展与展望。
Mol Cancer. 2013 Dec 3;12:152. doi: 10.1186/1476-4598-12-152.
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Central role of lactic acidosis in cancer cell resistance to glucose deprivation-induced cell death.乳酸酸中毒在癌细胞抵抗葡萄糖剥夺诱导的细胞死亡中的核心作用。
J Pathol. 2012 Jun;227(2):189-99. doi: 10.1002/path.3978. Epub 2012 Feb 17.
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The carcinogenicity of dichloroacetic acid in the male B6C3F1 mouse.二氯乙酸对雄性B6C3F1小鼠的致癌性。
Fundam Appl Toxicol. 1991 Feb;16(2):337-47. doi: 10.1016/0272-0590(91)90118-n.
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