新琼四糖通过调节肠道微生物组成和功能来保护小鼠免受剧烈运动引起的疲劳损伤。
Neoagarotetraose protects mice against intense exercise-induced fatigue damage by modulating gut microbial composition and function.
机构信息
College of Food Science and Engineering, Ocean University of China, Qingdao, China.
Animal Genomics and Improvement Laboratory, United States Department of Agriculture, Agriculture Research Service (USDA-ARS), Beltsville, MD, USA.
出版信息
Mol Nutr Food Res. 2017 Aug;61(8). doi: 10.1002/mnfr.201600585. Epub 2017 Mar 20.
SCOPE
Exhaustive exercise stress has emerged as an important health issue, and gastrointestinal problems are a common concern during intense exercise. In this study, we investigated the potential antifatigue effects of neoagarotetraose (NAT) in mice under intense exercise stress.
MATERIALS AND METHODS
Exhaustive exercise stress significantly weakened several physiological and physical parameters of the mice, including decreased food intake, reduced body weight, and impaired integrity of the intestinal epithelial barrier. Our data showed that a 16-day NAT treatment resulted in a profound change in microbiome composition, which subsequently led to widespread shifts in the functional potential of the gut microbiome. Furthermore, NAT administration significantly increased the fecal concentration of total short-chain fatty acids (p < 0.01).
CONCLUSION
Together, our findings suggest that NAT may protect mice against intense exercise-induced fatigue and provide insights into the mechanisms of NAT as a potential prebiotic.
范围
剧烈运动应激已成为一个重要的健康问题，而在剧烈运动期间，胃肠道问题是一个常见的关注点。在这项研究中，我们研究了 neoagarotetraose（NAT）在剧烈运动应激下的小鼠中的潜在抗疲劳作用。
材料和方法
剧烈运动应激显著削弱了小鼠的几项生理和物理参数，包括食物摄入量减少、体重减轻和肠道上皮屏障完整性受损。我们的数据显示，16 天的 NAT 处理导致微生物组组成发生深刻变化，随后导致肠道微生物组的功能潜力广泛变化。此外，NAT 给药显著增加了粪便中总短链脂肪酸的浓度（p < 0.01）。
结论
总之，我们的研究结果表明，NAT 可能保护小鼠免受剧烈运动引起的疲劳，并为 NAT 作为一种潜在的益生元的机制提供了新的见解。
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