Gordon Brittaney-Belle E, Chen Ronald C
a University of North Carolina at Chapel Hill School of Medicine , Chapel Hill , NC , USA.
b Department of Radiation Oncology , University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
Acta Oncol. 2017 Feb;56(2):166-173. doi: 10.1080/0284186X.2016.1268265. Epub 2017 Jan 13.
There are currently 33 million cancer survivors worldwide. With improvements in early cancer detection and treatments, patients are living longer - and it is well-recognized that many survivors develop short- and long-term physical, psychosocial and spiritual effects as a result of their diagnoses and treatments. There is increasing awareness of the importance of using patient-reported outcomes (PROs) to accurately assess these effects in cancer survivors. Validated patient-reported outcome instruments: Traditionally, physicians have assessed the acute and late side effects of cancer treatments with standardized scales such as the CTCAE. However, multiple studies have demonstrated that PROs more accurately capture patient symptoms than physician assessment. In this article we describe frequently used, validated, general and cancer-specific PRO instruments that assess symptoms. We describe additional PRO instruments that assess unmet needs, interpersonal relationship issues, and psychosocial and financial problems. Published studies using these instruments have identified issues commonly faced by cancer survivors worldwide. Discussion and summary: While PROs are increasingly used in research, further efforts are needed to integrate PRO assessment into routine clinical care, so that timely and accurate assessments can translate into better management of issues - ultimately improving the lives of cancer survivors.
目前全球有3300万癌症幸存者。随着早期癌症检测和治疗水平的提高，患者的生存期延长——而且人们普遍认识到，许多幸存者由于其癌症诊断和治疗而出现短期和长期的身体、心理社会及精神方面的影响。人们越来越意识到利用患者报告结局（PROs）来准确评估癌症幸存者的这些影响的重要性。经过验证的患者报告结局工具：传统上，医生使用诸如CTCAE等标准化量表来评估癌症治疗的急性和晚期副作用。然而，多项研究表明，与医生评估相比，PROs能更准确地反映患者症状。在本文中，我们描述了常用的、经过验证的、通用的和癌症特异性的评估症状的PRO工具。我们还描述了评估未满足需求、人际关系问题以及心理社会和财务问题的其他PRO工具。使用这些工具的已发表研究已经确定了全球癌症幸存者普遍面临的问题。讨论与总结：虽然PROs在研究中的应用越来越广泛，但仍需要进一步努力将PRO评估纳入常规临床护理，以便及时、准确的评估能够转化为对问题的更好管理——最终改善癌症幸存者的生活。
