Pandya Pahini, Orgaz Jose L, Sanz-Moreno Victoria
Tumour Plasticity Team, Randall Division of Cell and Molecular Biophysics, King's College London, UK.
Mol Oncol. 2017 Jan;11(1):5-27. doi: 10.1002/1878-0261.12019. Epub 2016 Dec 9.
Cancer cell migration and invasion underlie metastatic dissemination, one of the major problems in cancer. Tumour cells exhibit a striking variety of invasion strategies. Importantly, cancer cells can switch between invasion modes in order to cope with challenging environments. This ability to switch migratory modes or plasticity highlights the challenges behind antimetastasis therapy design. In this Review, we present current knowledge on different tumour invasion strategies, the determinants controlling plasticity and arising therapeutic opportunities. We propose that targeting master regulators controlling plasticity is needed to hinder tumour dissemination and metastasis.
癌细胞的迁移和侵袭是肿瘤转移扩散的基础，而肿瘤转移扩散是癌症的主要问题之一。肿瘤细胞表现出多种多样的侵袭策略。重要的是，癌细胞能够在不同侵袭模式之间切换，以应对具有挑战性的环境。这种迁移模式切换能力或可塑性凸显了抗转移治疗设计背后的挑战。在本综述中，我们介绍了关于不同肿瘤侵袭策略、控制可塑性的决定因素以及由此产生的治疗机会的现有知识。我们提出，需要靶向控制可塑性的主要调节因子来阻碍肿瘤的扩散和转移。
