放射疗法与免疫检查点抑制剂联合使用。
Radiotherapy in combination with immune checkpoint inhibitors.
作者信息
De Ruysscher Dirk, Reynders Kobe, Van Limbergen Evert, Lambrecht Maarten
机构信息
aMaastricht University Medical Center, Department of Radiation Oncology (Maastro Clinic), GROW School, Maastricht, The Netherlands bKU Leuven, Radiation Oncology cUniversity Hospitals Leuven, Department of Radiation Oncology/KU Leuven, Radiation Oncology, Leuven, Belgium.
出版信息
Curr Opin Oncol. 2017 Mar;29(2):105-111. doi: 10.1097/CCO.0000000000000352.
PURPOSE OF REVIEW
The immunomodulatory effects of ionizing radiation have long been recognized; however, so far these have not been fully exploited in clinical practice. We review the rationale to combine radiation with immune checkpoint inhibitors, which are used in standard practice.
RECENT FINDINGS
Preclinical research suggests a synergy between radiotherapy and these immune checkpoint inhibitors. Whether or not this benefit translates into a clinical benefit is currently subject of ongoing research.
SUMMARY
It is highly rational to combine radiation with immune therapy as in preclinical models and in proof of concept trials in humans it clearly can increase the antitumor immunity when given together with other immune interventions.
综述目的
长期以来，人们已经认识到电离辐射的免疫调节作用；然而，到目前为止，这些作用在临床实践中尚未得到充分利用。我们综述将放疗与免疫检查点抑制剂联合使用的基本原理，免疫检查点抑制剂在标准治疗中使用。
最新发现
临床前研究表明放疗与这些免疫检查点抑制剂之间存在协同作用。这种益处是否转化为临床益处目前正在研究中。
总结
放疗与免疫治疗联合是非常合理的，因为在临床前模型和人体概念验证试验中，放疗与其他免疫干预措施联合使用时显然可以增强抗肿瘤免疫力。
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