Grant Emma J, Nüssing Simone, Sant Sneha, Clemens E Bridie, Kedzierska Katherine
Department of Microbiology and Immunology, at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne 3000, VIC, Australia; Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom.
Department of Microbiology and Immunology, at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne 3000, VIC, Australia.
Curr Opin Virol. 2017 Feb;22:77-88. doi: 10.1016/j.coviro.2016.12.001. Epub 2017 Jan 12.
CD27 is a co-stimulatory immune-checkpoint receptor, constitutively expressed on a broad range of T-cells (αβ and γδ), NK-cells and B-cells. Ligation of CD27 with CD70 results in potent co-stimulatory effects. In mice, co-stimulation of CD8 T-cells through CD27 promotes immune activation and enhances primary, secondary, memory and recall responses towards viral infections. Limited in vitro human studies support mouse experiments and show that CD27 co-stimulation enhances antiviral T-cell immunity. Given the potent co-stimulatory effects of CD27, manipulating CD27 signalling is of interest for viral, autoimmune and anti-tumour immunotherapies. This review focuses on the role of CD27 co-stimulation in anti-viral T-cell immunity and discusses clinical studies utilising the CD27 co-stimulation pathway for anti-viral, anti-tumour and autoimmune immunotherapy.
CD27是一种共刺激免疫检查点受体，在多种T细胞（αβ和γδ）、自然杀伤细胞和B细胞上组成性表达。CD27与CD70结合会产生强大的共刺激作用。在小鼠中，通过CD27对CD8 T细胞进行共刺激可促进免疫激活，并增强对病毒感染的初次、二次、记忆和回忆反应。有限的体外人体研究支持小鼠实验，并表明CD27共刺激可增强抗病毒T细胞免疫。鉴于CD27强大的共刺激作用，操纵CD27信号传导对于病毒、自身免疫和抗肿瘤免疫疗法具有重要意义。本综述重点关注CD27共刺激在抗病毒T细胞免疫中的作用，并讨论利用CD27共刺激途径进行抗病毒、抗肿瘤和自身免疫免疫治疗的临床研究。
