Leppert D, Frei K, Gallo P, Yasargil M G, Hess K, Baumgartner G, Fontana A
Department of Neurology, University Hospital, Zurich, Switzerland.
J Neuroimmunol. 1989 Oct;24(3):259-64. doi: 10.1016/0165-5728(89)90124-0.
24 patients with neoplasia of the central nervous system (CNS-N) were investigated for the presence of B-cell stimulatory factor-2/interleukin-6 (IL-6) in the cerebrospinal fluid (CSF). Whereas IL-6 was detected in 21 (88%) of these CSF samples, only 6% of CSF from non-inflammatory brain diseases and 12% of the samples from multiple sclerosis patients were positive. IL-6 was found in both primary and secondary CNS-N. The presence of IL-6, a cytokine which activates B-lymphocytes to produce high-rate immunoglobulin (Ig) synthesis, is in contrast to the ineffective intrathecal B-cell activation as suggested by the failure to detect oligoclonal bands of Igs in CNS-N.
对24例中枢神经系统肿瘤（CNS-N）患者的脑脊液（CSF）进行了检测，以确定其中是否存在B细胞刺激因子2/白细胞介素-6（IL-6）。在这些CSF样本中，有21例（88%）检测到IL-6，而在非炎性脑部疾病的CSF中只有6%呈阳性，在多发性硬化症患者的样本中为12%呈阳性。原发性和继发性CNS-N中均发现了IL-6。IL-6是一种能激活B淋巴细胞以产生高速率免疫球蛋白（Ig）合成的细胞因子，然而CNS-N中未能检测到Ig的寡克隆带，提示鞘内B细胞激活无效，这与IL-6的存在形成了对比。
