Wintner Eliana Muskin, Hershko-Klement Anat, Tzadikevitch Keren, Ghetler Yehudith, Gonen Ofer, Wintner Oren, Shulman Adrian, Wiser Amir
IVF Unit, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel.
Affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
J Ovarian Res. 2017 Jan 13;10(1):2. doi: 10.1186/s13048-016-0297-9.
IVF cycles which result in only one good quality embryo, and a second poor quality embryo present a dilemma when the decision involves transferring two embryos. The aim of this study was to evaluate whether a poor quality embryo has a negative effect on a good quality embryo when transferred along with a good quality embryo.
We retrospectively evaluated in vitro fertilization (IVF) cycles involving single embryo transfers (SET) and double embryo transfers (DET). Embryo quality was divided into poor "P" and good "G" quality. The main outcome measures were: live birth, implantation rate, miscarriage rate, clinical pregnancy rate and multiple pregnancy ratio.
Six hundred three women were included. The study group consisted of 180 (29.9%) patients who had a double embryo transfer (DET) with one poor quality embryo and one good quality embryo (P + G). Control 1 group included 303 (50.2%) patients who had DET with two good quality embryos (G + G), and control 2 group consisted of 120 (19.9%) patients who had a single embryo transfer (SET) with one good quality embryo (G). Live birth rates were not significantly different when compared between study groups: 30.8% in the SET group (G), 27.2% in the (G + P) group and 33.7% in the (G + G) group. The SET group had the highest implantation rate (33.9%) compared to the DET groups (21.8% (G + P), 25.4% (G + G)) (P =0.022). The clinical pregnancy rate was 33.3% in the SET group (G), 33.3% in the (G + P) group, and 39.3% in the (G + G) group (P =0.39). The miscarriage rate was comparable in all groups.
A poor quality embryo does not negatively affect a good quality embryo, when transferred together in a double embryo transfer.
在体外受精（IVF）周期中，若仅产生一个优质胚胎和一个劣质胚胎，在决定是否移植两个胚胎时会面临两难境地。本研究的目的是评估在与优质胚胎一同移植时，劣质胚胎是否会对优质胚胎产生负面影响。
我们回顾性评估了涉及单胚胎移植（SET）和双胚胎移植（DET）的体外受精（IVF）周期。胚胎质量分为劣质“P”和优质“G”。主要观察指标为：活产率、着床率、流产率、临床妊娠率和多胎妊娠率。
共纳入603名女性。研究组由180名（29.9%）患者组成，她们进行了一个劣质胚胎和一个优质胚胎的双胚胎移植（DET）（P+G）。对照组1组包括303名（50.2%）进行两个优质胚胎双胚胎移植（DET）（G+G）的患者，对照组2组由120名（19.9%）进行一个优质胚胎单胚胎移植（SET）（G）的患者组成。各研究组间活产率无显著差异：SET组（G）为30.8%，（G+P）组为27.2%，（G+G）组为33.7%。与DET组相比，SET组着床率最高（33.9%）（DET组中，（G+P）组为21.8%，（G+G）组为25.4%）（P =0.022）。SET组（G）临床妊娠率为33.3%，（G+P）组为33.3%，（G+G）组为39.3%（P =0.39）。所有组的流产率相当。
在双胚胎移植中，劣质胚胎与优质胚胎一同移植时，不会对优质胚胎产生负面影响。
