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接触心理健康服务后青少年抑郁症的减少:英国的一项纵向队列研究。

Reduction in adolescent depression after contact with mental health services: a longitudinal cohort study in the UK.

作者信息

Neufeld Sharon A S, Dunn Valerie J, Jones Peter B, Croudace Tim J, Goodyer Ian M

机构信息

Department of Psychiatry, University of Cambridge, Cambridge, UK.

Department of Psychiatry, University of Cambridge, Cambridge, UK.

出版信息

Lancet Psychiatry. 2017 Feb;4(2):120-127. doi: 10.1016/S2215-0366(17)30002-0. Epub 2017 Jan 11.

Abstract

BACKGROUND

Evidence regarding the association between service contact and subsequent mental health in adolescents is scarce, and previous findings are mixed. We aimed to longitudinally assess the extent to which depressive symptoms in adolescents change after contact with mental health services.

METHODS

As part of a longitudinal cohort study, between April 28, 2005, and March 17, 2010, we recruited 1238 14-year-old adolescents and their primary caregivers from 18 secondary schools in Cambridgeshire, UK. Participants underwent follow-up assessment at months 18 and 36. Trained researchers assessed the adolescents for current mental disorder using the Schedule for Affective Disorders and Schizophrenia for School-Age Children Present and Lifetime version (K-SADS-PL). Caregivers and adolescents reported contact with mental health services in the year before baseline. Adolescents self-reported depressive symptoms (Mood and Feelings Questionnaire [MFQ]) at each timepoint. We assessed change in MFQ sum scores from baseline contact with mental health services using multilevel mixed-effects regression adjusted for sociodemographic, environmental, individual, and mental health confounders, with multiple imputation of missing data. We used propensity score weighting to balance confounders between treatment (users of mental health services) and control (non-users of mental health services) groups. We implemented an MFQ clinical cutoff following the results of receiver operating characteristic analysis.

FINDINGS

14-year-old adolescents who had contact with mental health services in the past year had a greater decrease in depressive symptoms than those without contact (adjusted coefficient -1·68, 95% CI -3·22 to -0·14; p=0·033). By age 17 years, the odds of reporting clinical depression were more than seven times higher in individuals without contact than in service users who had been similarly depressed at baseline (adjusted odds ratio 7·38, 1·73-31·50; p=0·0069).

INTERPRETATION

Our findings show that contact with mental health services at age 14 years by adolescents with a mental disorder reduced the likelihood of depression by age 17 years. This finding supports the improvement of access to adolescent mental health services.

FUNDING

Wellcome Trust, National Institute for Health Research.

摘要

背景

关于青少年的服务接触与随后心理健康之间关联的证据匮乏,且先前的研究结果不一。我们旨在纵向评估青少年在接触心理健康服务后抑郁症状的变化程度。

方法

作为一项纵向队列研究的一部分,在2005年4月28日至2010年3月17日期间,我们从英国剑桥郡的18所中学招募了1238名14岁青少年及其主要照顾者。参与者在18个月和36个月时接受随访评估。训练有素的研究人员使用《学龄儿童情感障碍和精神分裂症量表(目前和一生版)》(K-SADS-PL)对青少年当前的精神障碍进行评估。照顾者和青少年报告在基线前一年与心理健康服务的接触情况。青少年在每个时间点自我报告抑郁症状(情绪和感受问卷[MFQ])。我们使用多水平混合效应回归评估从基线接触心理健康服务到MFQ总分的变化,并对社会人口统计学、环境、个体和心理健康混杂因素进行调整,对缺失数据进行多重填补。我们使用倾向得分加权来平衡治疗组(心理健康服务使用者)和对照组(非心理健康服务使用者)之间的混杂因素。根据受试者工作特征分析的结果实施MFQ临床临界值。

结果

在过去一年中接触过心理健康服务的14岁青少年,其抑郁症状的减轻程度大于未接触过的青少年(调整系数-1·68,95%CI -3·22至-0·14;p=0·033)。到17岁时,未接触过服务的个体报告临床抑郁症的几率比基线时同样抑郁的服务使用者高出七倍多(调整后的优势比7·38,1·73 - 31·50;p=0·0069)。

解读

我们的研究结果表明,患有精神障碍的青少年在14岁时接触心理健康服务可降低到17岁时患抑郁症的可能性。这一发现支持改善青少年心理健康服务的可及性。

资金来源

惠康信托基金会、国家卫生研究院。

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