光响应按需给药系统的最新进展。
Recent advances in light-responsive on-demand drug-delivery systems.
作者信息
Linsley Chase S, Wu Benjamin M
机构信息
Department of Bioengineering, University of California, Los Angeles, CA 90095, USA.
Division of Advanced Prosthodontics & the Weintraub Center for Reconstructive Biotechnology, University of California, Los Angeles, CA 90095, USA.
出版信息
Ther Deliv. 2017 Feb;8(2):89-107. doi: 10.4155/tde-2016-0060.
Abstract
The convergence of wearable sensors and personalized medicine enhance the ability to sense and control the drug composition and dosage, as well as location and timing of administration. To date, numerous stimuli-triggered smart drug-delivery systems have been developed to detect changes in light, pH, temperature, biomolecules, electric field, magnetic field, ultrasound and mechanical forces. This review examines the major advances within the last 5 years for the three most common light-responsive drug delivery-on-demand strategies: photochemical, photoisomerization and photothermal. Examples are highlighted to illustrate progress of each strategy in drug delivery applications, and key limitations are identified to motivate future research to advance this important field.
摘要
可穿戴传感器与个性化医疗的融合提升了感知和控制药物成分、剂量以及给药位置和时间的能力。迄今为止，已经开发出了众多受刺激触发的智能药物递送系统，用于检测光、pH值、温度、生物分子、电场、磁场、超声和机械力的变化。本综述探讨了过去5年中三种最常见的按需光响应药物递送策略（光化学、光异构化和光热）方面的主要进展。文中突出了一些实例，以说明每种策略在药物递送应用中的进展，并指出了关键局限性，以推动未来的研究，促进这一重要领域的发展。
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