Baker Jonathon L, Bor Batbileg, Agnello Melissa, Shi Wenyuan, He Xuesong
School of Dentistry, University of California, Los Angeles, CA 90095, USA.
School of Dentistry, University of California, Los Angeles, CA 90095, USA; C3 Jian, Inc. Marina del Rey, CA 90292, USA.
Trends Microbiol. 2017 May;25(5):362-374. doi: 10.1016/j.tim.2016.12.012. Epub 2017 Jan 11.
Although great strides have been made in understanding the complex bacterial community inhabiting the human oral cavity, for a variety of (mainly technical) reasons the ecological contributions of oral fungi, viruses, phages, and the candidate phyla radiation (CPR) group of ultrasmall bacteria have remained understudied. Several recent reports have illustrated the diversity and importance of these organisms in the oral cavity, while TM7x and Candida albicans have served as crucial paradigms for CPR species and oral fungi, respectively. A comprehensive understanding of the oral microbiota and its influence on host health and disease will require a holistic view that emphasizes interactions among different residents within the oral community, as well as their interaction with the host.
尽管在了解人类口腔中复杂的细菌群落方面已经取得了巨大进展，但由于各种（主要是技术）原因，口腔真菌、病毒、噬菌体以及超小细菌的候选门辐射（CPR）组的生态贡献仍未得到充分研究。最近的几份报告已经阐明了这些生物体在口腔中的多样性和重要性，而TM7x和白色念珠菌分别作为CPR物种和口腔真菌的关键范例。要全面了解口腔微生物群及其对宿主健康和疾病的影响，需要一种整体观点，强调口腔群落中不同成员之间的相互作用，以及它们与宿主的相互作用。
