Gomez Andres, Nelson Karen E
Departments of Human Biology and Genomic Medicine, J. Craig Venter Institute, La Jolla, 92037, CA, USA.
Microb Ecol. 2017 Feb;73(2):492-503. doi: 10.1007/s00248-016-0854-1. Epub 2016 Sep 14.
In the era of applied meta-omics and personalized medicine, the oral microbiome is a valuable asset. From biomarker discovery to being a powerful source of therapeutic targets and to presenting an opportunity for developing non-invasive approaches to health care, it has become clear that oral microbes may hold the answer for understanding disease, even beyond the oral cavity. Although our understanding of oral microbiome diversity has come a long way in the past 50 years, there are still many areas that need to be fine-tuned for better risk assessment and diagnosis, especially in early developmental stages of human life. Here, we discuss the factors that impact development of the oral microbiome and explore oral markers of disease, with a focus on the early oral cavity. Our ultimate goal is to put different experimental and methodological views into perspective for better assessment of early oral and systemic disease at an early age and discuss how oral microbiomes-at the community level-could provide improved assessment in individuals and populations at risk.
在应用元组学和个性化医疗的时代，口腔微生物群是一项宝贵资产。从生物标志物的发现到成为治疗靶点的强大来源，再到为开发非侵入性医疗保健方法提供契机，很明显口腔微生物可能是理解疾病的关键，甚至超越口腔范围。尽管在过去50年里我们对口腔微生物群多样性的理解有了长足进步，但仍有许多领域需要进一步优化以实现更好的风险评估和诊断，尤其是在人类生命的早期发育阶段。在此，我们讨论影响口腔微生物群发育的因素，并探索疾病的口腔标志物，重点关注早期口腔。我们的最终目标是综合不同的实验和方法观点，以便更好地在早期评估儿童的早期口腔和全身疾病，并讨论在群落水平上口腔微生物群如何能为有风险的个体和人群提供更好的评估。
