Dun Rong-Liang, Yao Min, Yang Long, Cui Xue-Jun, Mao Jian-Min, Peng Yu, Qi Guang-Chong
Department of Urology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Spine Disease Institution, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Evid Based Complement Alternat Med. 2015;2015:689056. doi: 10.1155/2015/689056. Epub 2015 Jan 29.
Objective. The objective of this study was to conduct a systematic review to assess the effectiveness and safety of traditional Chinese herb combined with surgery for male varicocele infertility compared to surgery. Methods. Randomized controlled trials (RCTs) data of traditional Chinese herbs combined with surgery for male varicocele fertility versus surgery were collected by searching the Cochrane Library, Embase, PubMed, and Chinese databases. The risk of bias was assessed using Cochrane Handbook. Study outcomes were presented as risk ratios (RRs) for dichotomous data. Results. Seventeen of 72 potentially relevant trials met the inclusion criteria. The methodological qualities of the RCTs were low. Compared with the surgery group, the traditional Chinese herb combined with surgery group had superiority in pregnancy rate at 3-month (RR = 1.76, and P = 0.008), 6-month (RR = 1.58, and P = 0.0005), and 2-year (RR = 1.58, and P = 0.0005) follow-ups. No RCT was found to describe the side effects. Conclusion. On considering the low methodological quality of RCTs, there was no enough evidence on traditional Chinese herb with surgery for male varicocele infertility, and more high-quality RCTs of large sample sizes are required.
目的。本研究的目的是进行一项系统评价，以评估与手术相比，中药联合手术治疗男性精索静脉曲张性不育症的有效性和安全性。方法。通过检索考克兰图书馆、Embase、PubMed和中文数据库，收集中药联合手术治疗男性精索静脉曲张性不育症与单纯手术治疗的随机对照试验（RCT）数据。使用考克兰手册评估偏倚风险。二分数据的研究结果以风险比（RR）表示。结果。72项潜在相关试验中有17项符合纳入标准。RCT的方法学质量较低。与手术组相比，中药联合手术组在3个月（RR = 1.76，P = 0.008）、6个月（RR = 1.58，P = 0.0005）和2年（RR = 1.58，P = 0.0005）随访时的妊娠率方面具有优势。未发现RCT描述副作用。结论。考虑到RCT的方法学质量较低，尚无足够证据支持中药联合手术治疗男性精索静脉曲张性不育症，需要更多大样本的高质量RCT。
