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本文引用的文献

1
Preparation and evaluation of polyethyleneimine-single walled carbon nanotube conjugates as vectors for pancreatic cancer treatment.聚乙烯亚胺-单壁碳纳米管共轭物作为胰腺癌治疗载体的制备与评价
J Mater Chem B. 2014 Aug 7;2(29):4740-4747. doi: 10.1039/c4tb00778f. Epub 2014 Jun 18.
2
Meta-analysis of transcriptome data identifies a novel 5-gene pancreatic adenocarcinoma classifier.转录组数据的荟萃分析确定了一种新型的5基因胰腺癌分类器。
Oncotarget. 2016 Apr 26;7(17):23263-81. doi: 10.18632/oncotarget.8139.
3
Cancer statistics in China, 2015.《中国癌症统计数据 2015》
CA Cancer J Clin. 2016 Mar-Apr;66(2):115-32. doi: 10.3322/caac.21338. Epub 2016 Jan 25.
4
Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition.印楝素通过活性氧介导的细胞凋亡和抑制上皮-间质转化来抑制胰腺癌的生长和转移。
Sci Rep. 2016 Jan 25;6:19819. doi: 10.1038/srep19819.
5
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.联合抑制BET家族蛋白和组蛋白脱乙酰酶作为基于表观遗传学的胰腺癌潜在治疗方法。
Nat Med. 2015 Oct;21(10):1163-71. doi: 10.1038/nm.3952. Epub 2015 Sep 21.
6
Treatment of 200 locally advanced (stage III) pancreatic adenocarcinoma patients with irreversible electroporation: safety and efficacy.200 例局部晚期(III 期)胰腺腺癌患者接受不可逆电穿孔治疗的安全性和有效性。
Ann Surg. 2015 Sep;262(3):486-94; discussion 492-4. doi: 10.1097/SLA.0000000000001441.
7
Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma.尿液中用于早期检测胰腺腺癌的三生物标志物组合的鉴定
Clin Cancer Res. 2015 Aug 1;21(15):3512-21. doi: 10.1158/1078-0432.CCR-14-2467.
8
ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer.ERK激酶使胰腺癌中的肿瘤抑制因子FBW7磷酸化并使其不稳定。
Cell Res. 2015 May;25(5):561-73. doi: 10.1038/cr.2015.30. Epub 2015 Mar 10.
9
Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines.用抗IL-17RB抗体靶向IL-17B-IL-17RB信号通路可通过沉默多种趋化因子来阻断胰腺癌转移。
J Exp Med. 2015 Mar 9;212(3):333-49. doi: 10.1084/jem.20141702. Epub 2015 Mar 2.
10
Whole genomes redefine the mutational landscape of pancreatic cancer.全基因组重新定义了胰腺癌的突变格局。
Nature. 2015 Feb 26;518(7540):495-501. doi: 10.1038/nature14169.

胰腺癌:从实验室到临床

Pancreatic cancer: from bench to bedside.

作者信息

Ma Yaokai, Wu Qing, Li Xin, Gu Xiaoqiang, Xu Jiahua, Yang Jinzu

机构信息

Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.

出版信息

Ann Transl Med. 2016 Dec;4(23):458. doi: 10.21037/atm.2016.11.57.

DOI:10.21037/atm.2016.11.57
PMID:28090514
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5220038/
Abstract

Pancreatic cancer is recognized as the king of carcinoma, and the gap between basic research and clinical practice is difficult to improve the treatment effect. Translational medicine builds an important bridge between pancreatic cancer basic research and clinical practice from the pathogenesis, early diagnosis of pancreatic carcinoma, drug screening, treatment strategies and metastasis prediction. This article will carry on the concrete elaboration to the above several aspects.

摘要

胰腺癌被公认为癌中之王,基础研究与临床实践之间的差距难以提高治疗效果。转化医学从胰腺癌的发病机制、早期诊断、药物筛选、治疗策略及转移预测等方面,在胰腺癌基础研究与临床实践之间搭建了一座重要的桥梁。本文将对上述几个方面进行具体阐述。