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参松养心对阵发性心房颤动进展的影响与自主神经活动调节相关。

Effect of Shensong Yangxin on the Progression of Paroxysmal Atrial Fibrillation is Correlated with Regulation of Autonomic Nerve Activity.

作者信息

Zhao Hong-Yi, Zhang Shu-Di, Zhang Kai, Wang Xi, Zhao Qing-Yan, Zhang Shu-Juan, Dai Zi-Xuan, Qian Yong-Sheng, Zhang You-Jing, Wei Hao-Tian, Tang Yan-Hong, Huang Cong-Xin

机构信息

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060; Cardiovascular Research Institute, Wuhan University, Wuhan, Hubei 430060; Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, China.

Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.

出版信息

Chin Med J (Engl). 2017 Jan 20;130(2):171-178. doi: 10.4103/0366-6999.197997.

DOI:10.4103/0366-6999.197997
PMID:28091409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5282674/
Abstract

BACKGROUND

Shensong Yangxin (SSYX), a traditional Chinese herbal medicine, has long been used clinically to treat arrhythmias in China. However, the mechanism of SSYX on atrial fibrillation (AF) is unknown. In this study, we tested the hypothesis that the effect of SSYX on the progression of paroxysmal AF is correlated with the regulation of autonomic nerve activity.

METHODS

Eighteen mongrel dogs were randomly divided into control group (n = 6), pacing group (n = 6), and pacing + SSYX group (n = 6). The control group was implanted with pacemakers without pacing; the pacing group was implanted with pacemakers with long-term intermittent atrial pacing; the pacing + SSYX group underwent long-term intermittent atrial pacing and SSYX oral administration.

RESULTS

Compared to the pacing group, the parameters of heart rate variability were lower after 8 weeks in the pacing + SSYX group (low-frequency [LF] component: 20.85 ± 3.14 vs. 15.3 ± 1.89 ms 2 , P = 0.004; LF component/high-frequency component: 1.34 ± 0.33 vs. 0.77 ± 0.15, P < 0.001). The atrial effective refractory period (AERP) was shorter and the dispersion of the AERP was higher after 8 weeks in the pacing group, while the changes were suppressed by SSYX intake. The dogs in the pacing group had more episodes and longer durations of AF than that in the pacing + SSYX group. SSYX markedly inhibited the increase in sympathetic nerves and upregulation of tumor necrosis factor-alpha and interleukin-6 expression in the pacing + SSYX group. Furthermore, SSYX suppressed the decrease of acetylcholine and α7 nicotinic acetylcholine receptor protein induced by long-term intermittent atrial pacing.

CONCLUSIONS

SSYX substantially prevents atrial electrical remodeling and the progression of AF. These effects of SSYX may have association with regulating the imbalance of autonomic nerve activity and the cholinergic anti-inflammatory pathway.

摘要

背景

参松养心（SSYX）是一种传统中药，在中国长期用于临床治疗心律失常。然而，SSYX对心房颤动（AF）的作用机制尚不清楚。在本研究中，我们检验了以下假设：SSYX对阵发性AF进展的影响与自主神经活动的调节相关。

方法

18只杂种犬随机分为对照组（n = 6）、起搏组（n = 6）和起搏 + SSYX组（n = 6）。对照组植入起搏器但不进行起搏；起搏组植入起搏器并进行长期间歇性心房起搏；起搏 + SSYX组进行长期间歇性心房起搏并口服SSYX。

结果

与起搏组相比，起搏 + SSYX组在8周后心率变异性参数较低（低频[LF]成分：20.85±3.14对15.3±1.89 ms²，P = 0.004；LF成分/高频成分：1.34±0.33对0.77±0.15，P < 0.001）。起搏组在8周后心房有效不应期（AERP）较短且AERP离散度较高，而SSYX摄入可抑制这些变化。起搏组犬的AF发作次数更多、持续时间更长，而起搏 + SSYX组则不然。SSYX显著抑制了起搏 + SSYX组交感神经的增加以及肿瘤坏死因子-α和白细胞介素-6表达的上调。此外，SSYX抑制了长期间歇性心房起搏诱导的乙酰胆碱和α7烟碱型乙酰胆碱受体蛋白的减少。

结论

SSYX可显著预防心房电重构和AF进展。SSYX的这些作用可能与调节自主神经活动失衡和胆碱能抗炎途径有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/716f/5282674/4c1766875817/CMJ-130-171-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/716f/5282674/9f73d4bb0112/CMJ-130-171-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/716f/5282674/f72e9bd5acba/CMJ-130-171-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/716f/5282674/7d50a39a996b/CMJ-130-171-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/716f/5282674/e63d7df079e4/CMJ-130-171-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/716f/5282674/761d5219f815/CMJ-130-171-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/716f/5282674/4c1766875817/CMJ-130-171-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/716f/5282674/9f73d4bb0112/CMJ-130-171-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/716f/5282674/f72e9bd5acba/CMJ-130-171-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/716f/5282674/7d50a39a996b/CMJ-130-171-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/716f/5282674/e63d7df079e4/CMJ-130-171-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/716f/5282674/761d5219f815/CMJ-130-171-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/716f/5282674/4c1766875817/CMJ-130-171-g009.jpg

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3
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中医药在心血管疾病中的转化研究与临床应用
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