Parzeniecka-Jaworska M, Garncarz M, Kluciński W
Pol J Vet Sci. 2016 Dec 1;19(4):801-807. doi: 10.1515/pjvs-2016-0101.
The aim of this study was to determine if atrial natriuretic peptide can be used as an early screening tool for hypertrophic cardiomyopathy in Maine coon cats.
The study was performed in 43 Maine coon cats of both sexes, aged 11 to 92 months. Clinical and echocardiographic examinations were done and proANP serum concentrations were measured every three months over a period of one year (each cat had a total of five examinations). Cats were divided into 3 groups based on echocardiographic results: group 1 - healthy cats, group 2 - cats with unequivocal hypertrophic cardiomyopathy results, group 3 - cats with HCM. The study showed that the concentration of atrial natriuretic peptide correlates with the severity of HCM. A significant increase in serum concentration of this peptide was observed in cats from group 3, but it did not differ significantly between cats from group 2 and the healthy animals (p>0.05). A correlation was also found between proANP and age of the cats (p<0.01, r=0.5578) as well as between the ejection fraction (p=0.0285, r=0.5305) and end-systolic left ventricular diameter (p=0.05, r=0.48) in the affected animals. Atrial natriuretic peptide may be used to help in the diagnosis of advanced stages of HCM in Maine coon cats. Cats with high levels of proANP should be assigned to echocardiographic studies to confirm the disease.
本研究的目的是确定心房利钠肽是否可作为缅因猫肥厚型心肌病的早期筛查工具。
该研究对43只年龄在11至92个月的雌雄缅因猫进行。进行了临床和超声心动图检查，并在一年时间内每三个月测量一次血清前心钠素浓度（每只猫共进行五次检查）。根据超声心动图结果将猫分为3组：第1组——健康猫，第2组——肥厚型心肌病结果明确的猫，第3组——患有肥厚型心肌病的猫。研究表明，心房利钠肽的浓度与肥厚型心肌病的严重程度相关。在第3组的猫中观察到该肽的血清浓度显著升高，但第2组的猫与健康动物之间无显著差异（p>0.05）。在前心钠素与猫的年龄之间（p<0.01，r=0.5578）以及在受影响动物的射血分数（p=0.0285，r=0.5305）和收缩末期左心室直径之间（p=0.05，r=0.48）也发现了相关性。心房利钠肽可用于帮助诊断缅因猫肥厚型心肌病的晚期阶段。前心钠素水平高的猫应进行超声心动图检查以确诊疾病。
