MacLean Heidi N, Abbott Jonathan A, Ward Daniel L, Huckle William R, Sisson David D, Pyle R Lee
Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg 24061-0442, USA.
J Vet Intern Med. 2006 Mar-Apr;20(2):284-9. doi: 10.1892/0891-6640(2006)20[284:nanpii]2.0.co;2.
Atrial natriuretic peptide (ANP) is an important regulator of fluid homeostasis and vascular tone. We sought to compare N-terminal ANP immunoreactivity (ANP-IR) in plasma from cats with and without hypertrophic cardiomyopathy (HCM). Secondarily, we evaluated relationships between ANP-IR and echocardiographical variables in cats with HCM and healthy cats. Venous blood samples were obtained from 17 cats with HCM and from 19 healthy cats. Plasma ANP-IR concentration was determined by an enzyme-linked immunoassay. Two cats with HCM had clinical evidence of congestive heart failure; the remainder had subclinical disease. Plasma ANP-IR concentration was higher in cats with HCM (3,808 +/- 1,406 fmol/L, mean +/- SD) than in control cats (3,079 +/- 1,233 fmol/L), but this difference was not statistically significant (P = .11; 95% confidence interval [CI] = -166 to 1,622). There was a significant, but modest correlation between plasma ANP-IR concentration and left ventricular posterior wall thickness (r = 0.42; P = .01). Additionally, plasma ANP-IR concentration was weakly correlated with left atrial size (r = 0.35; P = .03). A linear regression model was developed to further explore these relationships. Atrial size and wall thickness were included in the model; the 2 explanatory variables had an interactive effect on plasma ANP-IR concentration (R2 = 0.27; P = .02). There was no appreciable correlation between plasma ANP-IR concentration and any other echocardiographical variable. In a population that included cats with subclinical disease, those with HCM did not have significantly higher plasma ANP-IR concentration than did healthy cats. An exploratory multivariable regression analysis suggested a linear relationship between ANP-IR concentration and atrial size, wall thickness, and their interaction.
心房利钠肽（ANP）是体液平衡和血管张力的重要调节因子。我们试图比较患有和未患有肥厚型心肌病（HCM）的猫血浆中的N端ANP免疫反应性（ANP-IR）。其次，我们评估了患有HCM的猫和健康猫中ANP-IR与超声心动图变量之间的关系。从17只患有HCM的猫和19只健康猫中采集静脉血样。采用酶联免疫吸附测定法测定血浆ANP-IR浓度。两只患有HCM的猫有充血性心力衰竭的临床证据；其余的患有亚临床疾病。患有HCM的猫血浆ANP-IR浓度（3808±1406 fmol/L，平均值±标准差）高于对照猫（3079±1233 fmol/L），但这种差异无统计学意义（P = 0.11；95%置信区间[CI]= -166至1622）。血浆ANP-IR浓度与左心室后壁厚度之间存在显著但适度的相关性（r = 0.42；P = 0.01）。此外，血浆ANP-IR浓度与左心房大小呈弱相关性（r = 0.35；P = 0.03）。建立了线性回归模型以进一步探讨这些关系。心房大小和壁厚度被纳入模型；这两个解释变量对血浆ANP-IR浓度有交互作用（R2 = 0.27；P = 0.02）。血浆ANP-IR浓度与任何其他超声心动图变量之间均无明显相关性。在包括患有亚临床疾病的猫的群体中，患有HCM的猫血浆ANP-IR浓度并不显著高于健康猫。一项探索性多变量回归分析表明ANP-IR浓度与心房大小、壁厚度及其相互作用之间存在线性关系。
