Watad Abdulla, Abu Much Arsalan, Bracco Danielle, Mahroum Naim, Comaneshter Doron, Cohen Arnon D, Amital Howard
Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel, Sackler Faculty of Medicine, Tel-Aviv University, 52621, Tel-Hashomer, Israel.
Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
Immunol Res. 2017 Apr;65(2):459-463. doi: 10.1007/s12026-016-8884-9.
Ischemic heart disease (IHD) is a well identified cause of mortality in systemic lupus erythematosus (SLE) patients due to an accelerated premature atherosclerosis. We investigated the proportion of comorbid IHD among SLE patients derived from a large, national real-life database. Using data from the largest HMO in Israel, the Clalit Health Services, we selected for patients with SLE. These patients were compared with age and sex matched controls with regards to the proportion of IHD in a case-control study. Chi-square and t tests were used for univariate analysis, and a logistic regression model was used for multivariate analysis. The study included 5018 patients with SLE and 25090 age and sex-frequency matched controls. The prevalence of IHD in patients with SLE was increased in comparison to controls (11.3 and 3.1%, P < 0.001). In a multivariate analysis, SLE was associated with IHD (OR 3.77, 95% confidence interval 3.34-4.26). We have confirmed that SLE patients suffer a high prevalence of IHD. Our data supports that SLE is an independent risk factor for IHD. When evaluating by gender, the risk seems even more substantial in females. No significant difference was found in the risk of IHD in SLE among the difference socioeconomic strata.
由于加速的过早动脉粥样硬化，缺血性心脏病（IHD）是系统性红斑狼疮（SLE）患者死亡率的一个明确原因。我们调查了来自一个大型全国性现实生活数据库的SLE患者中共患IHD的比例。利用以色列最大的健康维护组织（HMO）——克拉利特医疗服务公司的数据，我们挑选出了SLE患者。在一项病例对照研究中，将这些患者与年龄和性别匹配的对照组在IHD比例方面进行了比较。卡方检验和t检验用于单变量分析，逻辑回归模型用于多变量分析。该研究纳入了5018例SLE患者和25090例年龄和性别频率匹配的对照组。与对照组相比，SLE患者中IHD的患病率有所增加（分别为11.3%和3.1%，P < 0.001）。在多变量分析中，SLE与IHD相关（比值比3.77，95%置信区间3.34 - 4.26）。我们已经证实SLE患者中IHD的患病率很高。我们的数据支持SLE是IHD的一个独立危险因素。按性别评估时，女性的风险似乎更大。在不同社会经济阶层的SLE患者中，IHD风险未发现显著差异。
